Table 3.
Summary statistics of temporal profiles of glucose, insulin, C-peptide, glucagon, total GLP-1, and active GLP-1 for vehicle and exendin-(9-39) during MMTT and OPTT
| MMTT | P | OPTT | P | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Placebo | Exendin-(9-39) | Placebo | Exendin-(9-39) | |||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |||
| AUC glucose (mg ⋅ dL/min) | 26,259 | 3,306 | 33,470 | 3,498 | ≤0.001 | 12,570 | 1,318 | 18,540 | 1,621 | 0.01 |
| AUC insulin (pmol/L ⋅ min) | 25,811 | 6,507 | 25,227 | 5,597 | 0.827 | 14,584 | 4,141 | 27,797 | 6,139 | 0.004 |
| AUC C-peptide (pmol/L ⋅ min) | 171,367 | 22,443 | 179,653 | 29,360 | 0.534 | 139,776 | 24,075 | 183,620 | 17,283 | 0.059 |
| AUC glucagon (pg/mL ⋅ min) | 12,345 | 1,631 | 14,031 | 1,421 | ≤0.001 | 15,757 | 3,613 | 21,251 | 1,501 | 0.025 |
| AUC active GLP-1 (pmol/L ⋅ min) | 1,153 | 179 | 2,362 | 493 | ≤0.001 | 1,206 | 262 | 3,086 | 650 | ≤0.001 |
| AUC total GLP-1 (pmol/L ⋅ min) | 3,497 | 352 | 5,575 | 515 | ≤0.001 | 4,611 | 973 | 7,538 | 1,060 | ≤0.001 |
| AUC ISR (pmol/L ⋅ min) | 11,815 | 1,436 | 12,389 | 1,773 | 0.562 | 12,135 | 1,802 | 11,329 | 1,373 | 0.553 |
| FCR (1/min) | 0.219 | 0.086 | 0.264 | 0.072 | 0.383 | 0.309 | 0.071 | 0.225 | 0.051 | 0.017 |
| FPHE (%) | 75 | 6 | 54 | 8 | 0.008 | 48 | 9 | 54 | 8 | 0.566 |
Statistically significant findings are depicted in bold. ISR, insulin secretion rate.