Figure 1.

Trends in HbA_1c at baseline and at time of initiation of second diabetes medication. Points and vertical bars represent the mean and SD of HbA_1c for each year in the full sample (A) and among individuals initially treated with metformin at ages ≤55 years (B) and >55 years (C). Baseline values are shown in purple, and values nearest to the start of second-line diabetes treatment in those who were prescribed second-line treatment within 5 years are shown in green. The mean and SD values corresponding to each plotted point are shown below the plots, along with P values for temporal trends from models with adjustment for sex, race, and baseline age, HbA_1c, creatinine, and BMI.