Table 1.
Participant Characteristics at Cognitive Baseline
| Demographic characteristics, n (%) | Included | Excluded | p |
|---|---|---|---|
| Number of participants | 1139 | 21631 | 0.007 |
| Age, mean ± sd | 53.4 ± 2.6 | 53.7 ± 2.7 | |
| Race/Ethnicity | <.001 | ||
| Black | 294 (25.8) | 640 (29.6) | |
| White | 565 (49.6) | 986 (45.6) | |
| Chinese | 116 (10.2) | 134 (6.2) | |
| Hispanic | 0 (0) | 286 (13.2) | |
| Japanese | 164 (14.4) | 117 (5.4) | |
| Menopausal Status | <.001 | ||
| Post by BSO or hysterectomy | 54 (4.7) | 121 (10.7) | |
| Natural Post | 573 (50.3) | 669 (58.9) | |
| Late Peri | 139 (12.2) | 96 (8.5) | |
| Early Peri or Pre | 373 (32.7) | 250 (22.0) | |
| Education ≤ high school | 185 (16.2) | 634 (29.7) | <.001 |
| Somewhat/very hard to pay for basics | 291 (25.5) | 368 (32.9) | <.001 |
| Alcohol use ≥ 2/week | 261 (22.9) | 260 (23.1) | 0.921 |
| Current Smoker | 114 (10.0) | 180 (14.6) | 0.001 |
| Exposure characteristics, n (%) | |||
| n=7142 | |||
| Central obesity | 537 (47.1) | 367 (51.4) | 0.075 |
| Glucose ≥ 100 mg/dl | 188 (16.5) | 145 (20.3) | 0.038 |
| Diabetes | 82 (7.2) | 83 (11.6) | 0.001 |
| Triglycerides ≥ 150 mg/d | 239 (21.0) | 209 (29.3) | <.001 |
| HDL < 50 mg/dl (%) | 299 (26.3) | 203 (28.4) | 0.304 |
| Hyperlipidemia | 528 (46.4) | 332 (46.5) | 0.952 |
| Hypertension | 399 (35.0) | 330 (46.2) | <.001 |
| Heart age > Chronological age | 385 (33.8) | 342 (47.9) | <.001 |
| Cognitive outcomes at baseline | n=8593 | ||
| Symbol Digit Modalities, mean ± sd | 58.8 ± 10.3 | 55.2 ± 12.1 | <.001 |
| Digit Span Backward, mean ± sd | 7.0 ± 2.3 | 6.7 ± 2.3 | 0.012 |
| East Boston Memory Test: Delayed, median (IQR) | 10 (10, 12) | 10 (9, 12) | <.001 |
1.
Some characteristics contain missing data in the excluded group.
2.
Among excluded participants with CV risk factor data (n=714).
3.
Participant n for cognitive outcomes at baseline among those excluded ranges from n= 859 (Digit Span Backward) to n=912 (East Boston Memory Test).