Table 2.

Cognitive Test Score by CV Status at Cognitive Baseline (n=1139)

Exposure Status
	Symbol Digit Modalities, mean (SD)			Digit Span Backward, mean (SD)			Reverse-Scored East Boston Memory Test Delayed,1 median (Mean Wilcoxon Score)2
Exposure characteristic3	No	Yes	p	No	Yes	p	No	Yes	p
Central obesity	60.0 (10.0)	57.5 (10.5)	<.001	7.2 (2.3)	6.8 (2.3)	0.003	1 (539)	2 (605)	0.001
High glucose	59.1 (10.1)	57.1 (11.3)	0.024	7.1 (2.3)	6.5 (2.2)	0.004	1 (562)	2 (612)	0.051
Diabetes	59.2 (10.1)	53.9 (11.6)	<.001	7.0 (2.3)	6.1 (2.0)	<.001	1 (565)	2 (634)	0.061
High Triglycerides	58.9 (10.5)	58.6 (9.8)	0.777	7.0 (2.4)	6.9 (2.2)	0.472	1 (566)	2 (583)	0.464
Low HDL	58.9 (10.4)	58.5 (10.1)	0.568	7.0 (2.4)	6.9 (2.2)	0.343	1 (553)	2 (617)	0.003
Hyperlipidemia	59.3 (10.1)	58.2 (10.6)	0.068	7.0 (2.3)	6.9 (2.4)	0.559	1 (572)	2 (568)	0.856
Hypertension	60.1 (9.7)	56.4 (11.0)	<.001	7.1 (2.3)	6.7 (2.3)	0.002	1 (545)	2 (616)	<.001
Heart Age > Chronologic Age	60.0 (10.0)	56.5 (10.5)	<.001	7.2 (2.3)	6.6 (2.3)	<.001	1 (538)	2 (634)	<.001

Abbreviations: SD, standard deviation

^1.Scores from East Boston Memory Test are reversed and represent number of items missed.

^2.All medians (IQRs) for Reversed-EBMT Delayed tests were 1 (0, 2) for unexposed groups and 2 (0, 3) for exposed groups with the exception of hyperlipidemia, with median (IQR) of 1 (0,3) among unexposed and 2 (0,2) among exposed. To illustrate differences in distributions, median and mean Wilcoxon score for each group are displayed.

^3.Cut-points are as follows: Central obesity, waist circumference ≥ 80 cm for Japanese and Chinese women, and > 88 cm for all others; Glucose, ≥ 100 mg/dl; Diabetes, medication use or fasting glucose ≥ 126 mg/dl; High triglycerides, ≥ 150 mg/dl; Low HDL < 50 mg/dl, Hyperlipidemia, medication use or LDL ≥ 130 mg/dl; Hypertension, medication use or systolic ≥ 130 mmHg or diastolic ≥ 85 mmHg.