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. Author manuscript; available in PMC: 2022 Jun 21.
Published in final edited form as: Alcohol Clin Exp Res. 2019 Nov 1;43(12):2480–2493. doi: 10.1111/acer.14215

Figure 5.

Figure 5.

NMDAR1 mutant alleles do not block the acquisition of tolerance. Half of the animals were sedated with ethanol vapor 24h prior to the test, while the other half were mock-sedated. Tolerance is seen as a right-shift in the sedation curve of animals experiencing their second sedation. A through C are a recovery-from-sedation tolerance assays and D through F are sedation-tolerance assays. A) Animals homozygous for NMDAR1EP331 acquire tolerance (p < 0.0007). B) Animals homozygous for NMDAR1F654A acquire tolerance (p < 0.002). C) Animals homozygous for NMDAR1K558Q acquire tolerance (p < 0.0003). D) Animals homozygous for NMDAR1EP331 acquire tolerance (p < 0.04). E) Animals homozygous for NMDAR1F654A acquire tolerance (p < 0.003). F) Animals homozygous for NMDAR1K558Q acquire tolerance (p < 0.002).