Table 1:
Serum and Thyroid Gland PTU levels and Gland Hormone Concentrations
| PTU exposure duration/doses (ppm) 4 day | Serum PTU (ng/ml) | Gland PTU (ng/g) | Hormone Concentrations in the Thyroid Gland (ng/mg) | ||||
|---|---|---|---|---|---|---|---|
| MIT | DIT | T3 | rT3 | T4 | |||
| 0 | <0.381 | <71 | 35 (9) | 344 (96) | 18 (4) | 10 (2) | 207 (39) |
| 1 | 156 (20) | 4,246 (1170) | 30 (11) | 186 (66) * | 18 (6) | 9 (3) | 186 (30) |
| 3 | 459 (56) | 14,075 (2284) | 32 (7) | 142 (44) * | 13 (2) | 8 (2) | 65 (39) |
| 10 | 1,367 (139) | 20,055 (2725) | 12 (7) * | 94 (34) * | 5 (2) * | 3 (1) * | 48 (19) * |
| 7 day | |||||||
| 0 | <0.381 | <71 | 37 (12) | 640 (113) | 21 (4) | 6 (1) | 168 (27) |
| 1 | 138 (15) | 4,297 (1170) | 9 (1) * | 204 (29) * | 19 (3) | 5 (0.7) | 104 (20) |
| 3 | 412 (41) | 15,037 (2284) | 7 (1) * | 60 (23) * | 6 (1) * | 2 (0.5) | 27 (9) * |
| 10 | 1,589 (131) | 20,542 (2725) | 3 (1) * | 62 (26) * | 3 (1) * | 0.7 (0.3) * | 29 (9) * |
| 14 day | |||||||
| 0 | <0.381 | <71 | 14 (2) | 630 (60) | 24 (2) | 6 (1) | 164 (14) |
| 1 | 175 (49) | 4,867 (1170) | 13 (1) | 148 (36) * | 17 (2) * | 5 (0.8) | 51 (11) * |
| 3 | 453 (50) | 11,438 (2889) | 3 (1) * | 34 (16) * | 2 (0.5) * | 0.7 (0.3) * | 0.6 (0.4) * |
| 10 | 1,626 (113) | 13,800 (2725) | 4 (0.11) * | 6 (1) * | 0.1 (0.02) * | 0.1 (0.02) * | 0.2 (0.04) * |
Serum PTU LLOQ = 0.38 ng/ml; Gland PTU LLOQ = 7 ng/g Gland TH LLOQ = 0.5 ng/ml
*
indicates significantly different from control group where p<0.05
1
ppm = parts per million
2
PTU = 6-propylthiouracil; (n=8/dose/group)
MIT, 3-monoiodotyrosine, DIT, 3,5-diiodotyrosine, rT3, 3,3’,5’-triiodothyronine, T3, 3,3’,5-triiodothyronine, T4, thyroxine.