FIG 6.

Spatial flexibility model for peptidoglycan assembly. (a) Under basal conditions, PonA1 and RodA overlap substantially but not completely; new cell wall is assembled asymmetrically and enriched at the poles. (b, left and middle) Upon rodA deletion and aPBP inhibition, new cell wall assembly is disproportionally reduced at the poles. (b, right) Upon cell wall damage, MurG redistributes from the poles to the cell periphery, as does new cell wall. (c, left) In the absence of RodA, cell wall assembly is not shifted to the lateral cell under stress. (c, right) When aPBPs are inhibited, cell wall assembly redistributes upon damage.