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. 2022 Jun 3;13:856587. doi: 10.3389/fimmu.2022.856587

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Copyright © 2022 Maheshwari, Kumar, Jagdish, Nautiyal, Hidam, Kumari, Sehgal, Trehanpati, Baweja, Kumar, Sinha, Bajpai, Pamecha, Bihari, Maiwall, Sarin and Kumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of systemic inflammation and endotoxemia with monocyte mitochondrial respiration defects in patients with ACLF. (A) Dot plot showing changes in plasma level of pro-inflammatory and anti-inflammatory cytokines [tumor necrosis factor-alpha (TNF-α); interleukins (IL), 6, 12, 1β, 10, 1RA, 13, and 5] in the ACLF subgroups (ACLF, ACLF-SIRS, and ACLF-sepsis). (B) Dot plot showing changes in plasma endotoxin levels in the ACLF subgroups (ACLF, ACLF-SIRS, and ACLF-sepsis). (C) Real-time changes in oxygen consumption rate (OCR) with subsequent treatment with oligomycin (Oligo.) FCCP and rotenone and antimycin A (Rot. + AA.) in healthy monocytes treated with healthy plasma (hP), ACLF plasma (aP), and ACLF plasma with LPS (aP + LPS) (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001). n.s. stands for non-significant.