Table 5.
Changes in Individual Items of the HAMD-17 in Women (n = 42) Vs Men (n = 34) with TRDa
| Women | Men | Sex effect | Time effect | Sex × Time effect | |
|---|---|---|---|---|---|
| Depressed mood | 1.10 ± 0.13 | 0.83 ± 0.14 | F1,75 = 1.50, P = .22, η p2 = 0.02 | ***F1,70 = 101.27, P < .001, η p2 = 0.59 | F1,70 = 2.02, P = .16, η p2 = 0.02 |
| Feelings of guilt | 0.78 ± 0.12 | 0.56 ± 0.14 | F1,75 =1.03, P = .31, η p2 = 0.01 | ***F1,70 = 53.07, P < .001, η p2 = 0.44 | F1,70 = 1.49, P = .23, η p2 = 0.02 |
| Suicide | 0.92 ± 0.14 | 0.82 ± 0.16 | F1,75 = 3.29, P = .07, η p2 = 0.04 | ***F1,70 = 64.06, P < .001, η p2 = 0.48 | F1,70 = 0.22, P = .64, η p2 = 0.00 |
| Insomnia: early in the night | 0.71 ± 0.09 | 0.41 ± 0.10 | F1,75 = 0.86, P = .36, η p2 = 0.01 | ***F1,70 = 71.79, P < .001, η p2 = 0.52 | *F1,70 = 5.26, P = .03, η p2 = 0.08 |
| Insomnia: middle of the night | 0.76 ± 0.10 | 0.37 ± 0.11 | F1,75 = 2.58, P = .11, η p2 = 0.04 | ***F1,70 = 58.49, P < .001, η p2 = 0.47 | **F1,70 = 6.92, P = .01, η p2 = 0.09 |
| Insomnia: early hours of the morning | 0.43 ± 0.09 | 0.23 ± 0.10 | F1,75 = 0, P = .97, η p2 = 0.00 | *** F1,70 = 23.67, P < .001, η p2 = 0.25 | F1,70 = 2.14, P = .15, η p2 = 0.03 |
| Work and activities | 0.99 ± 0.16 | 0.74 ± 0.18 | F1,75 = 0.05, P = .82, η p2 = 0.00 | *** F1,70 = 50.69, P < .001, η p2 = 0.42 | F1,70 = 1.06, P = .31, η p2 = 0.02 |
| Retardation | 0.68 ± 0.08 | 0.22 ± 0.09 | F1,75 = 0.68, P = .41, η p2 = 0.01 | *** F1,70 = 54.34, P < .001, η p2 = 0.43 | ***F1,70 = 12.69. P < .001, η p2 = 0.16 |
| Agitation | 0.41 ± 0.09 | 0.24 ± 0.10 | F1,75 = 3.41, P = .07, η p2 = 0.05 | *** F1,70 = 25.72, P < .001, η p2 = 0.28 | F1,70 = 1.75, P = .19, η p2 = 0.03 |
| Anxiety psychic | 0.91 ± 0.12 | 0.50 ± 0.14 | F1,75 = 1.16, P = .29, η p2 = 0.02 | *** F1,70 = 59.67, P < .001, η p2 = 0.47 | *F1,70 = 5.21, P = .02, η p2 = 0.07 |
| Anxiety somatic | 0.84 ± 0.11 | 0.40 ± 0.12 | F1,75 = 0.10, P = .76, η p2 = 0.00 | *** F1,70 = 56.49, P < .001, η p2 = 0.47 | **F1,70 = 6.92, P = .01, η p2 = 0.10 |
| Somatic symptoms gastro-intestinal | 0.40 ± 0.10 | 0.25 ± 0.12 | F1,75 = 0.69, P = .41, η p2 = 0.00 | *** F1,70 = 16.84, P < .001, η p2 = 0.19 | F1,70 = 0.98, P = .32, η p2 = 0.01 |
| General somatic symptoms | 0.49 ± 0.11 | 0.18 ± 0.12 | F1,75 = 0.37, P = .55, η p2 = 0.01 | *** F1,70 = 14.95, P < .001, η p2 = 0.19 | F1,70 = 3.33, P = .07, η p2 = 0.04 |
| Genital symptoms | 0.09 ± 0.08 | 0.14 ± 0.09 | * F1,75 = 5.22, P = .03, η p2 = 0.07 | F1,70 = 3.49, P = .07, η p2 = 0.05 | F1,70 = 0.12, P = .72, η p2 = 0.00 |
| Hypochondriasis | 0.50 ± 0.11 | 0.41 ± 0.12 | F1,75 = 0.07, P = .80, η p2 = 0.00 | *** F1,70 = 30.66, P < .001, η p2 = 0.31 | F1,70 = 0.29, P = .58, η p2 = 0.00 |
| Loss of weight | 0.48 ± 0.12 | 0.28 ± 0.13 | F1,75 = 0.41, P = .53, η p2 = 0.00 | *** F1,70 = 19.3, P < .001, η p2 = 0.22 | F1,70 = 1.39, P = .24, η p2 = 0.02 |
| Insight | 0.15 ± 0.07 | 0.16 ± 0.07 | F1,75 = 0.37, P = .55, η p2 = 0.00 | *** F1,70 = 9.90, P < .001, η p2 = 0.13 | F1,70 = 0.02, P = .88, η p2 = 0.00 |
| Total change | 10.70 ± 0.90 | 6.74 ± 1.00 | F1,75 = 0.21, P = .64, η p2 = 0.00 | *** F1,70 = 167.5, P < .001, η p2 = 0.71 | **F1,67 = 8.55, P = .005, η p2 = 0.11 |
a Two-way ANOVAs with sex as between-subject factor and time as a within-subject factors, followed by Tukey post-hoc analyses. Delta scores (changes from T0 to T3) are reported. *P < .05, **P < .01, ***P < .001
Abbreviations: HAMD-17, 17-item Hamilton Depression Rating Scale; TRD, treatment-resistant depression.