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. 2022 Feb 4;25(6):489–497. doi: 10.1093/ijnp/pyac012

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© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — IL-mPFC controls extinction consolidation of recent fear memory and retrieval of remote fear memory. (A, C) Schematic presentation of the experimental protocol for recent (A) and remote (C) CFC memory and its extinction. (B, D) Behavioral results for animals whose infralimbic cortex was infused with vehicle (V), lidocaine (Lido), or anisomycin (Aniso) before or after T1, with infusion performed either 2 days (recent, C) or 28 days (remote, D) after conditioning. Infusion of lidocaine or anisomycin blocked extinction consolidation of recent CFC memory, and lidocaine infusion impaired retrieval of remote CFC memory. *Significantly different from the corresponding vehicle-treated group (P < .05).