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. 2022 Feb 4;25(6):489–497. doi: 10.1093/ijnp/pyac012

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© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Retrieval of remote, but not recent, fear memory enhances IL-mPFC activation. (A) Two days (recent) or 28 days (remote) after animals aged PND 27 were fear conditioned, fear memory was retrieved by replacing the animals in the conditioning context. At 90 minutes after retrieval (RET), animals were killed, and expression of c-Fos protein in the IL cortex was quantified using western blotting. C-Fos levels were similarly evaluated in unmanipulated home-cage animals of the same ages. (B, C) Representative blots of c-Fos and actin expression within the IL of naïve and fear conditioned animals after recent (B) or remote (C) retrieval and their corresponding controls. ***Remote retrieval significantly enhanced c-Fos expression in the IL cortex compared with recent retrieval and naive (home-cage) groups (P < .001).