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. 2022 Feb 13;25(6):498–511. doi: 10.1093/ijnp/pyac015

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© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effect of TB on scopolamine (SCOP)-induced impairment of LTP in HIP CA1 slices. (A) Effect of four 100-Hz pulses separated by 20 seconds (indicated by 4 arrows) on fEPSP slope in control (white circles, n = 6) and slices perfused with either 0.1 mM SCOP (gray circles, n = 5) or 0.1 mM TB + 0.1 mM SCOP (black circles, n = 6). The horizontal line represents the time during which TB and/or SCOP were perfused. The upper traces correspond to fEPSPs recorded during the basal period (a, thin trace), following HFS (b, thick trace), and final recording (c, dash trace) of a representative experiment for each case. Calibration: 1 mV, 1 ms. Comparison of fEPSP potentiation level (B) 10 minutes, (C) 100 minutes, and (D) 200 minutes after HFS. Data are expressed as means ± SEM. ***P < .001 compared with control group; ^###P < .001 compared with SCOP+TB group (1-way or 2-way ANOVA followed by post-hoc Bonferroni’s test).