Table 1.
The summary of MDM2 inhibitors and degraders
| No. | Name | Structure | Category | E3 ligase ligand | Target protein |
|---|---|---|---|---|---|
| 1 | Nutlin-3 |
|
Inhibitor | --a | -- |
| 2 | RG7388 |
|
Inhibitor | -- | -- |
| 3 | RG7112 |
|
Inhibitor | -- | -- |
| 4 | MI-77301 / SAR405838 |
|
Inhibitor | -- | -- |
| 5 | HDM201 |
|
Inhibitor | -- | -- |
| 6 | DS-3032b |
|
Inhibitor | -- | -- |
| 7 | APG-115 |
|
Inhibitor | -- | -- |
| 8 | MK-8242 |
|
Inhibitor | -- | -- |
| 9 | NVP-CGM097 |
|
Inhibitor | -- | -- |
| 10 | AMG-232 |
|
Inhibitor | -- | -- |
| 11 | WB214 |
|
Degrader | CRBN | MDM2 |
| 12 | TW-32 |
|
Degrader | CRBN | MDM2 |
| 13 | MD-224 |
|
Degrader | CRBN | MDM2 |
| 14 | MG-277 |
|
Degrader | CRBN | MDM2 |
| 15 | -- |
|
Degrader | Nutlin-3 | AR |
| 16 | A1874 |
|
Degrader | RG-7388 | BRD4 |
| 17 | -- |
|
Degrader | Nutlin-3 | PARP1 |
| 18 | -- |
|
Degrader | Nutlin-3 | MDM2 |
| 19 | -- |
|
Degrader | RG-7388 | EGFR |
| 20 | -- |
|
Degrader | Nutlin-3 | TRKC |
a
Not Applicable