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. Author manuscript; available in PMC: 2023 Mar 15.
Published in final edited form as: Chem Commun (Camb). 2022 Mar 15;58(22):3693–3696. doi: 10.1039/d2cc00660j

Fig 1.

Fig 1.

Schematic of the acylation at 2’-OH groups in RNA with activated carbonyl species, resulting in functionalized RNA. A rapid preequilibrium to form the oxyanion precedes acylation. Crystal structure of RNA was taken from22 PDB entry 1KFO.