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. 2022 Jun 17;14:297–309. doi: 10.2147/HIV.S362459

Table 4.

Multivariate Logistic Regression Analysis of Factors Associated with CVD Risk Factors, SPHMMC, Addis Ababa, 2020

Crude OR 95% CI P-value Adjusted OR 95% CI P-value
Hypertension
Age group 0.006 0.049*
<40 1 (R) 1 (R)
40–59 3.63 1.62–8.13 0.002 2.52 1.11–5.68 0.027*
≥60 3.64 1.17–11.28 0.025 3.59 1.08–11.95 0.037*
Male gender 0.41 0.23–0.73 0.003 2.767 1.37–5.59 0.005*
BMI 0.091 0.022*
Underweight 1 (R) 1 (R)
Normal 3.12 0.69–14 0.138 4.06 0.84–19.72 0.082
Overweight 3.53 0.77–16.24 0.105 5.26 1.02–27.05 0.047*
Obese 6.95 1.15–31.23 0.019 13.79 2.29–83.17 0.004*
Previous ART regimen 4.13 1.71–9.93 0.005 1.14 0.23–5.76 0.538
Current ART regimen 2.46 1.11–5.44 0.144 1.21 0.33–4.4 0.436
Elevated blood glucose
Age 0.015 0.056
<40 1 (R) 1 (R)
40–59 years 2.08 1.2–3.6 0.009 2.34 1.16–4.7 0.017
≥60 2.79 1.15–6.75 0.023 2.13 0.71–6.4 0.179
Elevated LDL cholesterol 1.79 1.08–2.98 0.024 0.85 0.4–1.83 0.683
Elevated total cholesterol 2.07 1.24–3.46 0.006 2.15 0.97–4.77 0.061
Current ART regimen 0.25 0.11–0.6 0.001 0.32 0.11–0.96 0.092
Previous ART regimen 0.49 0.2–1.21 0.194 0.37 0.6–2.24 0.68
CD4 count 0.32 0.08–1.25 0.09 0.148
<200 1 (R) 1 (R)
200–349 0.44 0.13–1.47 0.183 0.28 0.07–1.2 0.087
350–499 1.41 0.48–4.17 0.53 0.86 0.23–3.2 0.819
≥ 500 1.06 0.39–2.89 0.91 0.68 0.19–2.4 0.550
Dyslipidemia
Age group <0.001 <0.001*
<40 1 (R) 1 (R)
40–59 years 3.08 1.76–5.38 <0.001 3.61 1.95–6.72 <0.001*
≥60 2.4 0.91–6.33 0.077 2.45 0.86–7.01 0.094
Hypertension 1.54 0.8–2.95 0.193 1.06 0.5–2.28 0.873
BMI 0.031 0.044*
Underweight 1 (R) 1 (R)
Normal 1.29 0.54–3.06 0.565 1.53 0.6–3.9 0.375
Overweight 3.06 1.19–7.86 0.02 3.67 1.3–10.1 0.014*
Obese 1.75 0.57–5.32 0.327 2 0.58–6.86 0.277
Elevated blood glucose 1.2 0.66–2.17 0.036 1.13 0.59–2.17 0.097
Obesity
Age 0.761 0.941
<40 1 (R) 1 (R)
40–59 years 1.34 0.62–2.94 0.998 1.18 0.47–2.98 0.727
Hypertension 2.32 1.03–5.18 0.041 2.1 0.85–5.23 0.11
Previous ART regimen (TDF + 3TC + NVP) 9.05 3.01–27.23 <0.01 7.88 2.55–24.32 <0.001*
Metabolic syndrome
Age 0.039 0.051
<40 1 (R) 1 (R)
40–59 years 2.43 1.2–4.91 0.013 2.04 0.87–4.78 0.101
≥60 2.61 0.89–7.61 0.079 5 1.31–19.03 0.018
CD4 count 0.199 0.187
<200 1 (R) 1 (R)
200–349 0.2 0.04–0.99 0.049 0.15 0.03–0.85 0.032
350–499 0.76 0.21–2.72 0.672 0.53 0.13–2.12 0.372
≥ 500 0.64 0.2–2.04 0.455 0.53 0.15–1.83 0.315
BMI 0.05 0.029*
Underweight 1 (R) 1 (R)
Normal 4.55 0.58–35.7 0.15 4.02 0.49–32.68 0.194
Overweight 8.24 1.04–65.37 0.046 9.35 1.13–77.54 0.038*
Obese 11.2 1.26–99.26 0.03 12.17 1.28–115.5 0.03*

Note: *P-value <0.05.

Abbreviations: 3TC, Lamivudine; BMI, Body mass index; CD4, Cluster of differentiation 4; NVP, Nevirapine; OR, odds ratio; R, Reference; TDF, Tenofovir Disoproxil Fumarate.