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Pharmacokinetic and Pharmacodynamic of UPA
| Administration Route | Oral |
|---|---|
| JAK selectivity | JAK1 |
| Half-life | 4-hours |
| Metabolization | Hepatic, 80% |
| CYP3A4, CYP2D6 | |
| Urinary elimination | 24% |
| Fecal elimination | 38% |
| Renal impairment | |
| - CrCl >15 mL/min: | No dose adjustment |
| - CrCl <15 mL/min: | Not known |
| Liver impairment | |
| - Child-Pugh A-B | No dose adjustment |
| - Child-Pugh C | Not known |
| Administration during pregnancy and lactation | Not recommended |
Abbreviations: UPA, upadacitinib; CrCl, creatinine clearance.
