Table 1.
List of Assigned Statistically Significant Metabolites of the Intestine, Lung, Liver, Hippocampus, Cerebral Cortex, Inner Ear, Spleen, Kidney, Heart, and Serum with Differential Levels in the VPA and Control Groups
| Metabolites | HMDB | VIP | p-value | Fold Change |
|---|---|---|---|---|
| Intestine | ||||
| Myo-Inositol | HMDB0000211 | 2.04567 | 0.001 | 3.439350 |
| Lactic Acid | HMDB0000190 | 1.50743 | 0.005 | 2.270200 |
| 1-Monopalmitin | HMDB0011564 | 1.39394 | 0.012 | 2.190560 |
| Glycerol monostearate | HMDB0011535 | 1.13957 | 0.015 | 1.848520 |
| Cholesterol | HMDB0000067 | 1.12911 | 0.007 | 1.787470 |
| Lung | ||||
| Palmitic Acid | HMDB0000220 | 1.37692 | 0.009 | 0.741244 |
| Stearic Acid | HMDB0000827 | 1.06184 | 0.038 | 0.813081 |
| Liver | ||||
| Arachidonic Acid | HMDB0001043 | 1.39415 | 0.003 | 0.649100 |
| Pyroglutamic Acid | HMDB0000267 | 1.52309 | 0.024 | 0.549447 |
| Palmitelaidic Acid | HMDB0012328 | 1.64957 | 0.031 | 1.969660 |
| 5-Methyluridine | HMDB0000884 | 1.38951 | 0.031 | 0.575014 |
| 1-Monopalmitin | HMDB0011564 | 2.39767 | 0.009 | 0.247789 |
| Glycerol monostearate | HMDB0011535 | 1.99694 | 0.012 | 0.396780 |
| Hippocampus | ||||
| L-Alanine | HMDB0000161 | 1.82720 | 0.001 | 4.495780 |
| Malic acid | HMDB0000744 | 1.37611 | 0.004 | 2.312050 |
| L-Phenylalanine | HMDB0000159 | 1.59417 | 0.006 | 3.384310 |
| Lactic Acid | HMDB0000190 | 1.24282 | 0.009 | 2.000200 |
| L-Valine | HMDB0000883 | 1.90791 | 0.019 | 6.841520 |
| L-Isoleucine | HMDB0000172 | 1.98690 | 0.038 | 8.807450 |
| Serine | HMDB0062263 | 2.30428 | 0.005 | 23.592700 |
| L-Threonine | HMDB0000167 | 1.90837 | 0.015 | 6.223370 |
| L-Aspartic acid | HMDB0000191 | 1.74495 | 0.024 | 4.521630 |
| L-5-Oxoproline | HMDB0000267 | 2.05161 | 0.038 | 7.463970 |
| Anthranilic acid | HMDB0001123 | 1.77800 | 0.012 | 4.851230 |
| Cerebral Cortex | ||||
| Glycine | HMDB0000123 | 1.97603 | 0.004 | 2.884900 |
| Cysteine | HMDB0000574 | 1.23475 | 0.015 | 2.403990 |
| L-Alanine | HMDB0000161 | 1.43995 | 0.012 | 3.791640 |
| 2-Pyrrolidinone | HMDB0002039 | 1.68006 | 0.001 | 3.784290 |
| Serine | HMDB0062263 | 1.37677 | 0.019 | 2.922700 |
| L-Threonine | HMDB0000167 | 1.23958 | 0.030 | 2.908230 |
| 4-Aminobutanoic acid | HMDB0000112 | 1.59647 | 0.004 | 4.374060 |
| L-Glutamic acid | HMDB0000148 | 2.23040 | 0.000 | 29.447300 |
| Phosphorylethanolamine | HMDB0000224 | 1.76144 | 0.001 | 4.726210 |
| 9H-Purin-6-ol | HMDB0000157 | 1.71821 | 0.009 | 15.585400 |
| Inosine | HMDB0000195 | 1.00593 | 0.009 | 2.485920 |
| Inner Ear | ||||
| L-Valine | HMDB0000883 | 2.07651 | 0.044 | 0.375041 |
| Malic acid | HMDB0000744 | 1.56108 | 0.046 | 2.010810 |
| 4-Hydroxybutanoic acid | HMDB0000549 | 1.56809 | 0.009 | 2.161210 |
| Glyceric acid | HMDB0000139 | 2.17363 | 0.009 | 0.306473 |
| Serine | HMDB0062263 | 2.06863 | 0.038 | 0.365673 |
| Arachidonic acid | HMDB0001043 | 2.03148 | 0.001 | 2.053410 |
| Spleen | ||||
| 1-Monopalmitin | HMDB0011564 | 1.76956 | 0.012 | 0.386543 |
| Glycerol monostearate | HMDB0011535 | 1.76381 | 0.005 | 0.475034 |
| 4-Aminobutanoic acid | HMDB0000112 | 2.15469 | 0.038 | 0.407860 |
| Kidney | ||||
| 4-Aminobutanoic acid | HMDB0000112 | 1.08918 | 0.048 | 2.938670 |
| Arachidonic acid | HMDB0001043 | 1.37586 | 0.000 | 2.639280 |
| Doconexent | HMDB0002183 | 1.41469 | 0.000 | 2.905990 |
| L-Alanine | HMDB0000161 | 1.77298 | 0.007 | 396.480000 |
| L-Isoleucine | HMDB0000172 | 1.62704 | 0.015 | 14.185800 |
| L-Proline | HMDB0000162 | 1.75734 | 0.031 | 220.874000 |
| Uracil | HMDB0000300 | 1.75743 | 0.009 | 16.248300 |
| L-Threonine | HMDB0000167 | 1.76312 | 0.001 | 136.765000 |
| L-Aspartic acid | HMDB0000191 | 2.14945 | 0.004 | 6.702470 |
| Niacinamide | HMDB0001406 | 1.76298 | 0.012 | 36.932100 |
| L-Methionine | HMDB0000696 | 1.67178 | 0.009 | 27.566200 |
| L-5-Oxoproline | HMDB0000267 | 1.87337 | 0.000 | 259.595000 |
| L-Glutamic acid | HMDB0000148 | 1.78163 | 0.012 | 1248.860000 |
| L-Phenylalanine | HMDB0000159 | 1.68876 | 0.019 | 45.073100 |
| Asparagine | HMDB0000168 | 1.39873 | 0.000 | 0.404177 |
| Adonitol | HMDB0000508 | 1.05823 | 0.024 | 0.487813 |
| Phosphorylethanolamine | HMDB0000224 | 1.33412 | 0.005 | 4.524920 |
| Inosine | HMDB0000195 | 1.52390 | 0.001 | 0.269669 |
| Heart | ||||
| Lactic Acid | HMDB0000190 | 1.34498 | 0.034 | 0.667496 |
| Stearic acid | HMDB0000827 | 1.47295 | 0.003 | 0.708524 |
| L-Valine | HMDB0000883 | 2.22937 | 0.002 | 2.185800 |
| Serine | HMDB0062263 | 3.15764 | 0.001 | 6.630820 |
| L-Threonine | HMDB0000167 | 2.08688 | 0.015 | 2.179350 |
| L-Proline | HMDB0000162 | 2.38661 | 0.003 | 3.386840 |
| Inosine | HMDB0000195 | 1.22635 | 0.019 | 2.081900 |
| Serum | ||||
| Serine | HMDB0062263 | 1.63839 | 0.036 | 1.821870 |
| Urea | HMDB0000294 | 1.00209 | 0.031 | 2.956560 |
| 9,12-Octadecadienoic acid | HMDB0000673 | 1.96366 | 0.031 | 1.400160 |