TABLE 2.
Serum inflammatory biomarker levels and hematology at baseline and follow-up day seven in the two treatment groups.
| Biochemistry | Baseline (Day One) | Day Seven of Treatment | Test of Treatment Effect on Change | ||
|---|---|---|---|---|---|
| CQC Arm | Control Arm | CQC Arm | Control Arm | p-value | |
| CRP, median (IQR) (mg/dl)a | 34.0 (21.0, 45.0) | 36.0 (28.0, 47.0) | 11.0 (5.0, 16.0) | 22.0 (15.0, 25.0) | 0.006 |
| D-dimer, median (IQR) (ng/ml)b | 202.0 (160.0, 259.0) | 201.0 (150.0, 244.0) | 153.0 (130.0, 219.0) | 168.0 (140.0, 210.0) | 0.169 |
| LDH, median (IQR) (U/l)c | 381.0 (250.0, 622.0) | 335.0 (310.0, 465.0) | 219.0 (196.0, 264.0) | 243.0 (220.0, 301.0) | 0.289 |
| Ferritin, median (IQR) (ng/ml)d | 495.0 (400.0, 590.0) | 470.0 (413.0, 560.0) | 269.0 (217.0, 378.0) | 268.0 (165.0, 400.0) | 0.280 |
| Hematology | |||||
| Hemoglobin, median (IQR) (g/dl)e | 11.9 (11.0, 13.0) | 11.0 (11.0, 12.0) | 11.0 (10.1, 12.5) | 11.0 (10.8, 12.0) | 0.622 |
| Platelets, median (IQR) (×109 cells/l)f | 244.0 (230.0, 327.0) | 301.0 (230.0, 400.0) | 310.0 (255.0, 350.0) | 310.0 (234.0, 350.0) | 0.148 |
| Lymphocytes, median (IQR) (×109 cells/l)g | 9.0 (7.1, 10.0) | 11.0 (9.0, 11.6) | 8.6 (7.0, 10.0) | 9.5 (8.5, 12.0) | 0.745 |
| Leukocytes, median (IQR) (×109 cells/l)h | 36.0 (26.0, 43.0) | 20.0 (14.0, 34.0) | 24.0 (22.0, 25.0) | 23.0 (17.0, 25.0) | 0.680 |
| Neutrophils, median (IQR) (×109 cells/l)i | 56.0 (53.0, 65.0) | 71.0 (62.0, 76.0) | 71.0 (70.0, 72.0) | 71.0 (68.0, 74.0) | 0.219 |
Normal reference levels:
a
CRP: <0.50 mg/dl.
b
D-dimer: up to 198 ng/ml.
c
LDH: 120–220 U/L.
d
Ferritin: 20–250 ng/ml.
e
Hemoglobin: 13.5–17.5 g/dl (male); 12.15.5 g/dl (female).
f
Platelets: 150–450 (× 109 cells/l).
g
Lymphocytes: 4.0–11.0 (× 109 cells/l).
h
Leukocytes: 1.5–4.5 (× 109 cells/l).
i
Neutrophils: 2–7.5 (× 109 cells/l).