Table 2:
Depression and log-transformed relative leukocyte telomere length
| Cohorts | Depression | N | Model 1 | Model 2 | Model 3 | Model 4 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| % Difference (95% CI) | P-value | % Difference (95% CI) | P-value | % Difference (95% CI) | P-value | % Difference (95% CI) | P-value | |||
|
| ||||||||||
| BWHS | No | 635 | Ref | Ref | Ref | Ref | ||||
| Yes | 341 | −0.6 (−9.2, 8.2) | 0.89 | 0.0 (−8.7, 9.6) | 0.99 | −0.1 (−8.8, 9.5) | 0.99 | 1.9 (−7.0, 11.6) | 0.69 | |
| MASALA | No | 425 | Ref | Ref | Ref | Ref | ||||
| Yes | 48 | 2.4 (−15.0, 23.6) | 0.80 | 0.8 (−16.8, 22.1) | 0.94 | −0.7 (−18.0, 20.2) | 0.94 | 3.7 (−14.7, 26.0) | 0.71 | |
| NHSII | No | 900 | Ref | Ref | Ref | Ref | ||||
| Yes | 84 | 13.5 (−2.5, 32.3) | 0.10 | 12.9 (−3.2, 31.8) | 0.12 | 9.5 (−6.0, 27.5) | 0.64 | 10.7 (−5.2, 29.2) | 0.20 | |
| SHS | No | 328 | Ref | Ref | Ref | Ref | ||||
| Yes | 147 | 4.8 (−12.4, 25.2) | 0.61 | −6.6 (−23.5, 14.0) | 0.50 | −5.2 (−22.3, 15.7) | 0.60 | −5.3 (−22.8, 16.1) | 0.60 | |
| Pooled | No | 2288 | Ref | Ref | Ref | Ref | ||||
| Yes | 620 | 3.2 (−3.9, 10.5) | 0.37 | 2.0 (−4.9, 9.4) | 0.63 | 1.0 (−5.8, 8.3) | 0.76 | 3.0 (−3.9, 10.5) | 0.41 | |
| P-het | 0.53 | 0.46 | 0.67 | 0.67 | ||||||
BWHS
Model 1: Adjusted for agêModel 2: Model 1 plus employment status, income, and educational attainment; Model 3: Model 2 plus BMI, alternative healthy eating index with alcohol, and physical activity; Model 4: Model 3 plus the presence of hypertension and use of antidepressants.
MASALA
Model 1: Adjusted for age; Model 2: gender, employment status, income, and educational attainment; Model 3: Model 2 plus BMI, alternative health eating index, and physical activity; Model 4: Model 3 plus the presence of hypertension and use of antidepressants.
NHSII
Model 1 adjusted for age; Model 2: Model 1 plus employment status, and income; Model 3: Model 2 plus BMI, alternative health eating index, and physical activity; Model 4: Model 3 plus the presence of hypertension and use of antidepressants.
SHS
Model 1: Adjusted for age; Model 2: Model 1 plus gender, income, and educational attainment; Model 3: Model 2 plus BMI, alternative healthy eating index, and physical activity; Model 4: Model 3 plus the presence of hypertension, and use of antidepressants
P-het: p-value for heterogeneity between studies