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. 2022 May 9;66(6):e00222-22. doi: 10.1128/aac.00222-22

TABLE 2.

Amino acid substitutions with a frequency of ≥0.5% in Nsp12 Omicron sequences

Nsp12 change from WA1 reference isolate % (n) frequency in:
Omicron sequences All available sequencesa
P323L 99.5 (390,020) 98.4 (6,850,250)
F694Y 2.0 (7,822) 3.0 (205,649)
D153Y 0.97 (3,820) 0.10 (6,618)
Q875R 0.86 (3,352) 0.06 (4,286)
G44S 0.59 (2,319) 0.03 (2,336)
I223V 0.54 (2,109) 0.03 (2,333)
a

Based on a total of n = 7,106,062 sequences from GISAID on 18 January 2022.