TABLE 3.
RDV and GS-441524 potencies against recombinant Omicron SARS-CoV-2 viruses
| Virus | Mean EC50 ± SD (nM)a |
|
|---|---|---|
| RDV (n = 3–4) | GS-441524 (n = 3–4) | |
| WA1 | 94 ± 19 | 5,490 ± 800 |
| Omicron | 51 ± 22b | 3,510 ± 1,800b |
| rOmicron | 44 ± 9b | 2,440 ± 100b |
| rOmicron F694Y | 31 ± 5b | 1,900 ± 400b |
a
Values are the mean ± SD of the results from independent experiments. n represents the number of replicate experiments.
b
Statistically significant decrease (P ≤ 0.001) in EC50 value of Omicron and rOmicron viruses from the WA1 reference at 72 hpi by one-way ANOVA with Bonferroni correction for multiple comparisons. No statistical differences were observed between any of the Omicron and rOmicron viruses.