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. 2022 May 24;66(6):e00132-22. doi: 10.1128/aac.00132-22

FIG 3.

FIG 3

Lung CFU counts after 8 days of GSK2556286 treatment in an acute infection model in C57BL/6 mice. Data points represent individual mouse results. Open triangles represent mice from an initial experiment with a higher dose range. Solid circles represent mice from a second experiment with a lower, but overlapping, dose range. Solid lines represent fitted sigmoidal dose-response (A) and whole-blood exposure-response (B) curves, where AUClast is the AUC0–24. Horizontal dotted lines show thresholds for a 2-log10 reduction in CFU compared to untreated mice and the lower limit of CFU detection, as indicated.