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In vitro activity of GSK2556286 under various conditions
| Compound | IC50 (μM) against M. tuberculosis strain H37Rv or Erdman |
||||
|---|---|---|---|---|---|
| Intracellular activity of H37Rv in THP-1 cells | Extracellular activity |
||||
| H37Rv |
Erdman |
||||
| Glucose medium | Cholesterol medium | Glucose medium | Cholesterol medium | ||
| GSK2556286 | 0.07 | >125 | 2.12 | >50 | 0.71 |
| Rifampicin | 0.0008 | 0.15 | 0.2 | 0.1 | 0.1 |
| Moxifloxacin | 0.16 | 0.11 | 0.5 | 0.28 | 0.4 |
