TABLE 2.

Antitubercular drug activity against selected GSK2556286-resistant M. tuberculosis strains in liquid medium

Drug	Activity against M. tuberculosis strainc
	EM05b	EM08a	EM10a	EM19a	EM33b	EM63a
Moxifloxacin	0.4	0.4	0.3	0.4	0.5	0.3
Linezolid	0.7	0.7	0.8	0.6	1.6	1.2
Pretomanid	1.0	1.0	1.0	1.4	1.7	1.4
Rifampicin	0.9	0.9	0.9	0.9	1.4	1.4
Bedaquiline	2.2	2.2	1.7	1.0	2.2	2.2
Ethionamide	1.4	1.4	0.9	1.2	1.7	0.9
Ethambutol	1.6	1.6	1.4	1.9	1.7	1.1
Kanamycin	0.4	0.4	0.5	0.5	0.4	0.8
Streptomycin	0.6	0.5	0.6	0.8	0.8	0.6
Amikacin	0.3	0.3	0.4	0.3	0.3	0.4
d-Cycloserine	1.0	0.8	0.8	1.1	0.8	0.9
PAS	1.1	1.3	1.0	0.6	0.4	0.8

^acya mutation confirmed.

^bThe presence or absence of a cya mutation remains to be confirmed.

^cActivity is presented as the ratio of the IC₉₀ of the mutant/IC₉₀ of wild-type EM01.