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Antitubercular drug activity against selected GSK2556286-resistant M. tuberculosis strains infecting THP-1 cells
| Compound | Activity against M. tuberculosis strainc |
|
|---|---|---|
| EM19a | EM33b | |
| Isoniazid | 0.57 | 0.54 |
| Rifampicin | 0.77 | 0.47 |
| Moxifloxacin | 0.32 | 0.30 |
cya mutation confirmed.
The presence or absence of a cya mutation remains to be confirmed.
Activity is presented as the ratio of the IC50 of the mutant/IC50 of wild-type EM01.
