TABLE 2.

Cumulative fraction of response (CFR) of echinocandins against Candida spp. in critically ill patients with different weights using net fungal stasis target

Antifungal	Dosing regimen (mg/day)	Cumulative fraction of response (%) against Candida spp. according to wt (kg)a
		C. albicans			C. glabrata			C. parapsilosis			C. tropicalis			C. krusei			C. auris
		50	75	100	50	75	100	50	75	100	50	75	100	50	75	100	50	75	100
Caspofungin	70/50b	90.4	88.5	88.5	99.0	99.0	99.0	64.6	61.8	19.3
	100 q48h	88.7	88.5	88.4	99.0	99.0	99.0	63.2	60.8	14.5
	100/70	98.5	98.2	93.2	99.7	99.7	99.2	64.7	64.6	64.2
	150 q48h	98.5	98.4	95.3	99.7	99.7	99.3	65.1	64.6	64.3
	100	98.5	98.5	98.4	99.7	99.7	99.7	89.2	86.5	64.7
	200 q48h	98.5	98.5	98.5	99.7	99.7	99.7	90.1	88.7	65.9
	150	99.4	99.4	98.8	99.7	99.7	99.7	90.8	90.8	90.7
Micafungin	100b	62.3	18.3	10.2	71.7	20.5	11.2	11.0	7.9	3.6	41.1	10.5	4.9	2.9	0.5	0.1	94.3	94.3	94.2
	200 q48h	63.0	25.6	10.4	72.5	29.0	11.3	11.0	9.0	3.9	41.6	15.6	5.0	2.9	0.9	0.1	94.3	94.3	94.3
	300 q72h	63.0	28.3	10.5	72.5	32.2	11.4	11.0	9.5	4.5	41.7	17.5	5.1	2.9	1.0	0.1	94.3	94.3	94.3
	150	65.6	62.9	57.6	74.5	72.4	66.2	22.2	11.0	10.9	45.3	41.6	37.9	3.7	2.9	2.6	94.3	94.3	94.3
	300 q48h	67.3	63.1	59.8	75.8	72.6	68.7	25.1	11.2	10.9	47.7	41.7	39.4	4.3	2.9	2.7	94.3	94.3	94.3
	200	88.3	71.1	63.6	91.7	78.6	72.9	34.3	25.6	13.1	78.0	53.2	42.4	11.2	5.5	3.1	94.3	94.3	94.3
	250	88.5	87.7	75.7	91.8	91.2	82.1	34.5	34.2	28.6	78.3	77.1	59.8	11.3	11.0	7.1	94.3	94.3	94.3
	300	88.9	88.4	87.1	92.0	91.8	90.7	55.9	34.4	33.9	79.3	78.2	76.2	14.2	11.3	10.8	94.3	94.3	94.3
Anidulafunginc	200/100b		68.2			69.0			4.0			94.8
	250 q48h		72.5			75.2			4.1			95.1
	350 q72h		71.4			73.7			4.1			95.1
	200/150		75.6			79.6			4.9			95.6
	300 q48h		75.5			79.4			4.8			95.6
	200		81.8			86.3			6.1			96.8
	250		89.7			93.9			6.7			97.4
	300		92.0			95.7			7.6			97.7

^aBoldface indicates CFR of ≤90%. Body weights are given as 50, 75, and 100 kg.

^bConventional dose for echinocandins.

^cCFR values for anidulafungin are calculated regardless of weight.