TABLE 4.

Pharmacodynamics targets and MIC distributions of echinocandins for Candida spp.

Candida species	Antifungal agent	PK/PD targets (fAUC0–24/MIC)	PK/PD targets in sensitivity analysis	Percentage of isolates at an MIC (μg/mL) of:											ECV	MIC breakpoint
				0.008	0.016	0.031	0.063	0.125	0.25	0.5	1	2	4	8
C. albicans	Caspofungin	22.4	25.9	0.7	16.2	45.7	25.9	10.0	0.9	0.4	0.1	0.1
	Micafungin	12.5	25.2	9.5	53.6	25.4	5.9	2.3	1.9	1.0	0.3	0.1
	Anidulafungin	27.8	91	9.2	31.4	34.4	17.2	5.0	1.6	0.9	0.3	0.1
	Fluconazole	25	100												0.5	2
	Voriconazole	25													0.03	0.064
C. glabrata	Caspofungin	2.9	13.5		1.2	58.5	23.3	13.0	2.5	0.5	0.7		0.2	0.2
	Micafungin	12.5	9.45	10.3	62.3	19.2	4.0	1.3	0.8	0.6	0.5	0.6	0.4
	Anidulafungin	13.7	32	0.1	2.5	27.2	49.1	17.0	1.5	0.4	0.9	0.8	0.4
	Fluconazole	25	100												8
	Voriconazole	25													0.25
C. parapsilosis	Caspofungin	16.8	35.5		0.4	1.4	10.4	52.4	26.2	8.8	0.4
	Micafungin	0.7125	7.73		0.7	0.2	0.4	1.4	8.3	23.3	45.4	19.3	0.9
	Anidulafungin	11.5	22		0.4	1.7	1.9	2.7	4.9	13.6	30.2	38.3	6.1	0.1
	Fluconazole	25	100												1	2
	Voriconazole	25													0.03	0.125
C. tropicalis	Anidulafungin	6.1		7.4	22.0	38.4	20.5	6.9	2.3	1.6	0.5	0.4
	Micafungin	12.5		4.4	37.3	36.6	16.8	3.4	0.9	0.1	0.4		0.1	0.1
	Fluconazole	25	100												1	2
	Voriconazole	25													0.12	0.125
C. krusei	Micafungin	12.5			2.9	8.4	48.1	32.1	7.6	0.5	0.3
	Voriconazole	25													0.5	0.5
C. auris	Micafungin	0.13	0.33		3.3	3.3	38.2	39.8	7.3	1.6	0.8			5.7