Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inactivation of KPC-53 and KPC-3 by avibactam, tazobactam, and clavulanic acid
| Inhibitor | KPC-53 |
KPC-3a |
|||||
|---|---|---|---|---|---|---|---|
| k+3 (s−1) | k+2/K (M−1 s−1) | k+2 (s−1) | k+3 (s−1) | k+2/K (M−1 s−1) | K (M) | Ki (μM) | |
| Avibactam | 0.0008 | 6.3 | 74 | 0 | 6.8 × 103 | 1.1 × 10−2 | ND |
| Tazobactam | 0.0004 | 2 × 102 | – | – | – | – | – |
| Clavulanic acid | 0.0016 | 3 × 102 | ND | ND | ND | ND | 41 |
–, acted as a substrate; ND, not determined.
