TABLE 3.
Ceftriaxone pharmacokinetic model parameter estimatesa
| Parameter | Mean (SD) | Median | 95% CI | % RSE | CV% | Shrinkage (%) |
|---|---|---|---|---|---|---|
| TVNR (L/h) | 7.27 (4.89) | 6.86 | 5.73–8.77 | 11.21 | 67.29 | 7.79 |
| TVR (L/h) | 4.12 (5.47) | 1.98 | 2.25–5.67 | 22.13 | 132.75 | 4.30 |
| V (L) | 7.43 (3.25) | 7.25 | 6.45–8.33 | 7.29 | 43.66 | 18.50 |
| Kon (L/mg/h) | 1,290.19 (472.19) | 1,312.04 | 1,169–1,412 | 6.10 | 36.60 | 27.56 |
| Koff (h−1) | 18,537.17 (4507.28) | 18,961.57 | 17,177–19,916 | 4.05 | 24.32 | 17.95 |
| Kcp (h−1) | 4.00 (3.20) | 3.04 | 3.15–4.89 | 13.33 | 80.01 | 24.15 |
| Kpc (h−1) | 0.65 (0.53) | 0.48 | 0.49–0.80 | 13.59 | 81.23 | 16.97 |
| N | 0.82 (0.43) | 0.69 | 0.69–0.94 | 8.74 | 51.71 | 21.84 |
a
95% CI, 95% bootstrapped confidence interval; TVNR, nonrenal ceftriaxone clearance; TVR, renal ceftriaxone clearance; V, volume of distribution; Kon, second-order association rate constant; Koff, first-order dissociation rate constant; Kcp, rate transfer constant from the central to peripheral compartment; Kpc, rate transfer constant from the peripheral to central compartment; N, number of ceftriaxone binding sites per albumin molecule; SD, standard deviation; RSE, residual squared error; CV, coefficient of variation.