TABLE 5.

Probability of toxicity within a 7-day treatment course^a

Dose	CLCR (mL/min)	Albumin (g/L)	Probability of achieving total Cmin of >100 mg/L
1 g q24h	20	20	0
	20	30	0
	20	40	0
	40	20	0
	40	30	0
	40	40	0
	100	20	0
	100	30	0
	100	40	0
	160	20	0
	160	30	0
	160	40	0
2 g q24h	20	20	0
	20	30	0
	20	40	0
	40	20	0
	40	30	0
	40	40	0
	100	20	0
	100	30	0
	100	40	0
	160	20	0
	160	30	0
	160	40	0
1 g q12h	20	20	0
	20	30	0
	20	40	0
	40	20	0
	40	30	0
	40	40	0
	100	20	0
	100	30	0
	100	40	0
	160	20	0
	160	30	0
	160	40	0
2 g q12h	20	20	0.01
	20	30	0.01
	20	40	0.01
	40	20	0.01
	40	30	0.01
	40	40	0.01
	100	20	0
	100	30	0
	100	40	0
	160	20	0
	160	30	0
	160	40	0
1 g q8h	20	20	0.01
	20	30	0.01
	20	40	0.01
	40	20	0
	40	30	0
	40	40	0
	100	20	0
	100	30	0
	100	40	0
	160	20	0
	160	30	0
	160	40	0
2 g q8h	20	20	0.06
	20	30	0.06
	20	40	0.06
	40	20	0.01
	40	30	0.01
	40	40	0.01
	100	20	0.01
	100	30	0.01
	100	40	0.01
	160	20	0
	160	30	0
	160	40	0
1-g LD + 2-g CI	20	20	0
	20	30	0
	20	40	0
	40	20	0
	40	30	0
	40	40	0
	100	20	0
	100	30	0
	100	40	0
	160	20	0
	160	30	0
	160	40	0
1-g LD + 4-g CI	20	20	0.03
	20	30	0.03
	20	40	0
	40	20	0.01
	40	30	0.01
	40	40	0.01
	100	20	0.01
	100	30	0.01
	100	40	0.01
	160	20	0
	160	30	0
	160	40	0

^aLD, loading dose; CI, continuous infusion; CL_CR, creatinine clearance; q8h, q12h, and q24h, administered every 8, 12, and 24 h, respectively.