TABLE 2.
Population pharmacokinetic parameters of the final modela
| Parameter | Value |
||||
|---|---|---|---|---|---|
| Final model |
1,000 bootstrap runs |
||||
| Mean value | RSE (%) | Shrinkage (%) | Bootstrap median | 95% CI | |
| Remdesivir | |||||
| Metabolic CL (L/h) | 207 | 13 | 209 | 152–279 | |
| Renal CL (L/h) | 20.7 fixed | ||||
| V (L) | 157 | 19 | 164 | 98.9–259 | |
| GS-441524 | |||||
| CL (L/h) | 27.6 | 17 | 28.1 | 20.7–38.9 | |
| eGFR on CL | 1.76 | 22 | 1.68 | 0.31–2.91 | |
| V (L) | 1,060 | 11 | 1,062 | 834–1,270 | |
| Interindividual variability (%) | |||||
| Remdesivir nonrenal CL | 38.9 | 22 | 12 | 37.9 | 18.9–51.5 |
| Remdesivir V | 47.9 | 23 | 24 | 44.9 | 17.1–62.3 |
| GS-441524 CL | 47.4 | 29 | 28 | 41.7 | 17.5–57.8 |
| GS-441524 V | 42.9 | 17 | 0 | 41.8 | 14.6–56.7 |
| Residual variability | |||||
| Remdesivir | 0.0294 | 12 | 0.0269 | 0.0091–0.0468 | |
| GS-441524 | 0.0140 | 11 | 0.0136 | 0.0083–0.0189 | |
a
CL, clearance; V, volume of distribution; RSE, relative standard error.