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. 2022 Jun 2;13:883483. doi: 10.3389/fphar.2022.883483

TABLE 1.

Operational definitions.

Terms Operational definitions
Mono-drug resistant TB TB patients are non-responsive to a single anti-TB drug other than H and R in FLDs
Poly-drug resistant (PDR) TB TB patients are non-responsive to more than one FLDs, not including H and R
Rifampicin resistant (RR) TB TB patient non-responsive to R only
Multidrug resistant TB (MDR-TB TB patient non-responsive to both H and R
Extensive drug-resistant TB (XDR-TB) TB patient non-responsive to any FQs and any of the injectable SLDs (Am, Km, and Cm) in addition to H and R
Cured DR-TB patient completes the TB treatment without any sign of therapy failure and obtains at least five consecutive negative sputum cultures in the final treatment year taken a month apart
Treatment completed DR-TB patient completes the TB treatment with inadequate bacteriological results (less than five negative cultures in the final year of treatment) but without any sign of therapy failure
Died DR-TB patient expires during the period of TB treatment
Treatment failed DR-TB patient obtains two or even more positive cultures out of the five cultures during the last year of therapy or if there is a lack of improvement in therapeutic response
Defaulted A gap of two or more consecutive months in the treatment of a DR-TB patient due to non-medical reasons
Successful outcomes Cured or treatment completed
Unsuccessful outcomes Died or treatment failed or defaulted
Married Legally recognized union between people called spouses
Unmarried Without any legally recognized union

TB, tuberculosis; FLDs, first-line anti TB drugs; SLDs, second-line anti TB drugs; H, isoniazid; R, rifampicin; FQs, fluoroquinolones; Am, amikacin; Km, kanamycin; Cm, capreomycin.