TABLE 3.

Inhibition of Plasmodium falciparum growth in infected human erythrocytes^a

Test agents		IC50 (nM)
	Particle size	Chloroquine-sensitive 3D7			Multidrug-resistant Dd2
	Mean (μm)	Mean	SD	P value	Mean	SD	P value
Artemisinin	n/a	7.900	2.260		15.910	3.730
Chloroquine	n/a	32.060	11.030		364.500	45.080
DMSO dissolved DQ	n/d	1.410	0.390		2.630	1.880
Nanoformulation DQ	0.21	2.100	1.330		3.110	0.860
HME DQ (F15)	0.47	2.390	1.230		3.530	0.740
Artemisinin verusus HME DQ				0.021			0.005
DMSO DQ versus Nano DQ				0.437			0.708
DMSO DQ VS HME DQ				0.259			0.483

^aF15 DQ was more potent than artemisinin and chloroquine against two different P. falciparum strains in the in vitro test (P < 0.05). F15 DQ had inhibitory potency comparable to DMSO dissolved DQ and nano-DQ (P > 0.05). Each value represents triplicate and the experiment repeated multiple times; n/d, not detectable; n/a, not applicable.