TABLE 4.
Inhibitory effects of the DQ HME formulations on different strains of P. falciparum expressed as the half-maximal inhibition concentration (IC50)a
| Formulations/drugs |
F8 |
F15 |
Chloroquine |
Artemisinin |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 (nM) | Mean | n | SD | Mean | n | SD | Mean | n | SD | Mean | n | SD |
| Pf3D7 | 2.09 | 5 | 0.69 | 2.51 | 5 | 0.54 | 57.45 | 3 | 0.13 | 23.12 | 3 | 0.81 |
| PfDd2 | 3.41 | 3 | 0.29 | 2.53 | 5 | 0.82 | 243.90 | 3 | 6.08 | 26.01 | 3 | 0.85 |
| Pf803 | 2.65 | 8 | 0.42 | 1.89 | 3 | 0.40 | 957.20 | 3 | 132.20 | 32.00 | 3 | 0.85 |
| PfB74F6 (PS) | 2.33 | 3 | 0.75 | 1.47 | 3 | 0.15 | 79.20 | 3 | 4.45 | 14.47 | 3 | 3.57 |
| PfB74D6 (PS) | 2.68 | 3 | 0.79 | 1.70 | 3 | 0.64 | 78.15 | 3 | 7.03 | 25.44 | 3 | 1.77 |
| PfB64G11 (PS) | 2.21 | 3 | 0.48 | 0.45 | 3 | 0.11 | 30.38 | 3 | 0.14 | 6.66 | 3 | 1.54 |
| PfB74C4 (PS) | 4.07 | 4 | 0.98 | 0.32 | 3 | 0.13 | 59.29 | 3 | 0.74 | 26.41 | 3 | 0.60 |
| PfB12D9 (PS) | 3.47 | 4 | 0.61 | 1.64 | 3 | 0.50 | 63.30 | 3 | 4.03 | 24.12 | 3 | 1.80 |
a
Pf: Plasmodium falciparum; 3D7, chloroquine-sensitive strain; Dd2, multiple drug resistance; 803, chloroquine resistance; PS, patients’ blood samples.