TABLE 6.
Components of DQ HME formulationsa
| Formulation | Soluplus (g) | VA 64 (g) | HPMC (g) | Others (g) | DQ (g) |
|---|---|---|---|---|---|
| 1 | 30 | 130 (15LV) | 20 (PEG6000) | 20 | |
| 2 | 27 | 113 (15LV) | 20 (PEG6000) | 40 | |
| 3 | 30 | 130 (4M) | 20 (PEG6000) | 20 | |
| 4 | 27 | 113 (4M) | 20 (PEG6000) | 40 | |
| 5 | 90 (15LV) | 15 (P188), 15 (RH 40) | 30 | ||
| 6 | 105 (15LV) | 15 (RH 40) | 30 | ||
| 7 | 28 | 70 (AS-912) | 15 (PEG6000) | 37 | |
| 8 | 28 | 70 (AS-126) | 15 (PEG6000) | 37 | |
| 9 | 25 | 105 | 14 (PGGS), 6 (P188) | 50 | |
| 10 | 120 (EPO) | 30 | |||
| 11 | 30 | 120 (EPO) | 50 | ||
| 12 | 30 | 130 | 20 (PEG6000) | 20 | |
| 13 | 27 | 113 | 20 (PEG6000) | 40 | |
| 14 | 74 | 37 | 10 (PGGS) | 30 | |
| 15 | 87 | 43 | 20 (PEG6000) | 50 |
a
Soluplus, polyvinyl caprolactam-polyvinyl acetatepolyethylene glycol graft copolymer; VA 64, vinylpyrrolidone/vinylacetate copolymer; HPMC, hydroxypropyl methyl cellulose; 15LV, HPMC HME 15LV; 4M, HPMC HME 4M; AS-912, HPMCAS-912; AS-126, HPMCAS-126; PEG 6000, polyethylene glycol 6000; P188, Poloxam 188 (Kolliphor P188); RH40, polyoxyl 40 hydrogenated castor oil; PGGS, polyethylene glycol glyceryl stearate (Gelucire 50/13); EPO, dimethylaminoethyl methacrylate copolymer (EUDRAGIT EPO).