TABLE 2.
Description of ISL static selection experiments with subtype B viruses containing known NRTI resistance mutationsa
| Expt no. | Virus | No. of replicates | ISL concentrations tested (nM) | No. of passages |
|---|---|---|---|---|
| 1 | WT, M184I, or M184V | 8 | 50.0, 25.0, 12.5, 6.25, 3.13, 1.56, 0.781, 0.391, 0.195, 0.0977, 0.0490, 0.0244 | 18 |
| 2 | WT, M184I, M184V, L74I, or V90I | 16 | 50.0, 25.0, 12.5 | 19 |
| 3 | K65R | 16 | 50.0, 25.0, 12.5 | 17 |
| 4 | WT, M184I, M184V, or L74I | 16 | 50.0, 25.0, 12.5 | 11 |
a
ISL, islatravir, also known as MK-8591; NRTI, nucleoside reverse transcriptase inhibitor; WT, wild-type R8 virus.