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Recommended Lumasiran Regimens Based on Body Weight, Currently Approved in the US and EU
| Body Weight | Loading Dose | Maintenance Dose (Begin 1 Month After the Last Loading Dose) |
|---|---|---|
| Less than 10 kg | 6 mg/kg once monthly for 3 doses | 3 mg/kg once monthly |
| 10 kg to less than 20 kg | 6 mg/kg once monthly for 3 doses | 6 mg/kg once every 3 months (quarterly) |
| 20 kg and above | 3 mg/kg once monthly for 3 doses | 3 mg/kg once every 3 months (quarterly) |
