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. 2022 Jun 21;13:3556. doi: 10.1038/s41467-022-31210-w

Fig. 5. The fit of protease inhibitors within the substrate envelope.

Fig. 5

a PF-07321332 (35), PDB ID:7RFS, b PF-00835231 (36), PDB ID 6XHM. c Noncovalent potent compound 21 (37), PDB ID: 7L13. d Moonshot compound 11 (38), PDB ID 7NW2. The inhibitors are in ball-and-stick representation and the substrate envelope is depicted as the blue volume. The catalytic dyad residues are labeled in bold while the underlined labels are for the residues that interact with one or more inhibitor and may be vulnerable to resistance.