Table 2.
Associations Between Indicators and OS in All Females with Cancer
| Characteristics | Model 1a | P value | Model 2b | P value | Model 3c | P value |
|---|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| ALI | ||||||
| Continuousd | 0.64 (0.57, 0.72) | < 0.001 | 0.77 (0.68, 0.87) | < 0.001 | 0.83 (0.73, 0.94) | 0.004 |
| Highd | 0.38 (0.32, 0.45) | < 0.001 | 0.55 (0.45, 0.67) | < 0.001 | 0.62 (0.51, 0.77) | < 0.001 |
| Quartile 2d | 0.53 (0.42, 0.66) | < 0.001 | 0.67 (0.53, 0.85) | 0.001 | 0.71 (0.56, 0.91) | 0.006 |
| Quartile 3d | 0.38 (0.30, 0.48) | < 0.001 | 0.55 (0.43, 0.72) | < 0.001 | 0.65 (0.49, 0.86) | 0.002 |
| Quartile 4d | 0.27 (0.20, 0.35) | < 0.001 | 0.42 (0.31, 0.56) | < 0.001 | 0.50 (0.36, 0.69) | < 0.001 |
| P for trend | 0.64 (0.59, 0.69) | < 0.001 | 0.75 (0.68, 0.82) | < 0.001 | 0.80 (0.72, 0.88) | < 0.001 |
| SII | ||||||
| Continuousd | 1.35 (1.27, 1.44) | < 0.001 | 1.23 (1.14, 1.32) | < 0.001 | 1.18 (1.09, 1.27) | < 0.001 |
| Highe | 2.51 (2.10, 3.01) | < 0.001 | 1.92 (1.59, 2.33) | < 0.001 | 1.72 (1.41, 2.10) | < 0.001 |
| Quartile 2e | 1.27 (0.96, 1.68) | 0.093 | 1.33 (0.99, 1.79) | 0.062 | 1.29 (0.95, 1.74) | 0.097 |
| Quartile 3e | 1.20 (0.90, 1.60) | 0.213 | 1.06 (0.78, 1.43) | 0.731 | 0.95 (0.69, 1.29) | 0.729 |
| Quartile 4e | 2.88 (2.23, 3.71) | < 0.001 | 2.12 (1.61, 2.79) | < 0.001 | 1.78 (1.34, 2.38) | < 0.001 |
| P for trend | 1.42 (1.30, 1.54) | < 0.001 | 1.26 (1.15, 1.37) | < 0.001 | 1.18 (1.08, 1.30) | < 0.001 |
| mGNRI | ||||||
| Continuousd | 0.64 (0.57, 0.72) | < 0.001 | 0.76 (0.66, 0.88) | < 0.001 | 0.80 (0.69, 0.92) | 0.002 |
| Highf | 0.46 (0.38, 0.55) | < 0.001 | 0.54 (0.42, 0.69) | < 0.001 | 0.59 (0.46, 0.76) | < 0.001 |
| Quartile 2f | 0.64 (0.51, 0.81) | < 0.001 | 0.61 (0.46, 0.8) | < 0.001 | 0.64 (0.49, 0.84) | 0.001 |
| Quartile 3f | 0.48 (0.38, 0.61) | < 0.001 | 0.42 (0.30, 0.59) | < 0.001 | 0.47 (0.34, 0.67) | < 0.001 |
| Quartile 4f | 0.29 (0.22, 0.38) | < 0.001 | 0.34 (0.22, 0.51) | < 0.001 | 0.40 (0.27, 0.60) | < 0.001 |
| P for trend | 0.67 (0.62, 0.73) | < 0.001 | 0.69 (0.6, 0.79) | < 0.001 | 0.73 (0.64, 0.84) | < 0.001 |
| AGR | ||||||
| Continuesd | 0.66 (0.60, 0.73) | < 0.001 | 0.75 (0.68, 0.83) | < 0.001 | 0.78 (0.70, 0.86) | < 0.001 |
| Highg | 0.47 (0.39, 0.56) | < 0.001 | 0.60 (0.50, 0.73) | < 0.001 | 0.63 (0.52, 0.76) | < 0.001 |
| Quartile 2g | 0.74 (0.59, 0.92) | 0.008 | 0.80 (0.63, 1.02) | 0.07 | 0.87 (0.68, 1.11) | 0.257 |
| Quartile 3g | 0.48 (0.38, 0.62) | < 0.001 | 0.55 (0.42, 0.72) | < 0.001 | 0.59 (0.45, 0.78) | < 0.001 |
| Quartile 4g | 0.37 (0.29, 0.48) | < 0.001 | 0.54 (0.41, 0.70) | < 0.001 | 0.57 (0.44, 0.76) | < 0.001 |
| P for trend | 0.71 (0.66, 0.77) | < 0.001 | 0.79 (0.73, 0.87) | < 0.001 | 0.81 (0.74, 0.89) | < 0.001 |
| PNI | ||||||
| Continuousd | 0.65 (0.60, 0.71) | < 0.001 | 0.76 (0.69, 0.83) | < 0.001 | 0.79 (0.72, 0.87) | < 0.001 |
| Highh | 0.44 (0.36, 0.53) | < 0.001 | 0.61 (0.50, 0.76) | < 0.001 | 0.66 (0.53, 0.82) | < 0.001 |
| Quartile 2h | 0.59 (0.47, 0.74) | < 0.001 | 0.66 (0.52, 0.84) | 0.001 | 0.70 (0.55, 0.89) | 0.004 |
| Quartile 3h | 0.46 (0.36, 0.59) | < 0.001 | 0.64 (0.5, 0.83) | 0.001 | 0.71 (0.55, 0.93) | 0.013 |
| Quartile 4h | 0.31 (0.24, 0.41) | < 0.001 | 0.48 (0.37, 0.64) | < 0.001 | 0.53 (0.40, 0.71) | < 0.001 |
| P for trend | 0.68 (0.63, 0.74) | < 0.001 | 0.80 (0.73, 0.87) | < 0.001 | 0.83 (0.75, 0.90) | < 0.001 |
| LCR | ||||||
| Continuousd | 0.62 (0.51, 0.75) | < 0.001 | 0.76 (0.64, 0.91) | 0.002 | 0.81 (0.68, 0.96) | 0.013 |
| Highi | 0.38 (0.32, 0.45) | < 0.001 | 0.55 (0.45, 0.66) | < 0.001 | 0.61 (0.50, 0.74) | < 0.001 |
| Quartile 2i | 0.66 (0.53, 0.82) | < 0.001 | 0.82 (0.65, 1.04) | 0.103 | 0.87 (0.69, 1.11) | 0.268 |
| Quartile 3i | 0.39 (0.30, 0.50) | < 0.001 | 0.55 (0.43, 0.71) | < 0.001 | 0.61 (0.47, 0.80) | < 0.001 |
| Quartile 4i | 0.24 (0.19, 0.32) | < 0.001 | 0.43 (0.32, 0.58) | < 0.001 | 0.49 (0.36, 0.66) | < 0.001 |
| P for trend | 0.62 (0.57, 0.68) | < 0.001 | 0.75 (0.68, 0.82) | < 0.001 | 0.78 (0.71, 0.86) | < 0.001 |
| CONUT | ||||||
| Lightj | 1.42 (1.13, 1.80) | 0.003 | 1.19 (0.93, 1.52) | 0.176 | 1.18 (0.92, 1.52) | 0.193 |
| Moderatej | 2.82 (2.08, 3.83) | < 0.001 | 2.24 (1.62, 3.11) | < 0.001 | 2.00 (1.42, 2.83) | < 0.001 |
| Severej | 3.27 (1.65, 6.48) | 0.001 | 2.36 (1.02, 5.44) | 0.045 | 2.18 (0.93, 5.09) | 0.073 |
| P for trend | 1.20 (1.15, 1.25) | < 0.001 | 1.44 (1.23, 1.69) | < 0.001 | 1.11 (1.06, 1.17) | < 0.001 |
| mGPS | ||||||
| 1 | 1.83 (1.45, 2.32) | < 0.001 | 1.25 (0.98, 1.61) | 0.076 | 1.21 (0.94, 1.55) | 0.146 |
| 2 | 3.30 (2.61, 4.18) | < 0.001 | 2.19 (1.70, 2.82) | < 0.001 | 1.89 (1.45, 2.47) | < 0.001 |
| P for trend | 1.82 (1.62, 2.04) | < 0.001 | 1.44 (1.27, 1.64) | < 0.001 | 1.35 (1.18, 1.54) | < 0.001 |
| LCS | ||||||
| 1 | 2.59 (1.98, 3.38) | < 0.001 | 1.70 (1.28, 2.27) | < 0.001 | 1.57 (1.18, 2.09) | 0.002 |
| 2 | 5.26 (3.85, 7.20) | < 0.001 | 2.66 (1.9, 3.72) | < 0.001 | 2.35 (1.66, 3.31) | < 0.001 |
| P for trend | 2.26 (1.94, 2.62) | < 0.001 | 1.62 (1.38, 1.9) | < 0.001 | 1.53 (1.29, 1.81) | < 0.001 |
Notes: aModel 1 was not adjusted for any covariates. bModel 2 was adjusted for age, body mass index, type of cancer, smoking status, alcohol consumption and TNM stage. cModel 3 was adjusted for age, body mass index, type of cancer, smoking status, alcohol consumption, TNM stage, history of surgery, radiotherapy and chemotherapy, Karnofsky performance status score and Scored Patient-Generated Subjective Global Assessment. dContinuous: as continuous variable; Low: < 23.727; High: ≥ 23.727; Quartile 1: < 22.875; Quartile 2: 22.875 ~ < 38.805; Quartile 3: 38.805 ~ < 61.579; Quartile 4: ≥ 61.579. eContinuous: as continuous variable; Low: < 930.286; High: ≥ 930.286; Quartile 1: < 317.797; Quartile 2: 317.797 ~ < 533.433; Quartile 3: 533.433 ~ < 929.343; Quartile 4: ≥ 929.343. fContinuous: as continuous variable; Low: < 46.858; High: ≥ 46.858; Quartile 1: < 42.460; Quartile 2: 42.460 ~ < 47.856; Quartile 3: 47.856 ~ < 55.432; Quartile 4: ≥ 55.432. gContinuous: as continuous variable; Low: < 1.232; High: ≥ 1.232; Quartile 1: < 1.173; Quartile 2: 1.173 ~ < 1.354; Quartile 3: 1.354 ~ < 1.546; Quartile 4: ≥ 1.546. hContinuous: as continuous variable; Low: < 48.700; High: ≥ 48.700; Quartile 1: < 43.600; Quartile 2: 43.600 ~ < 47.450; Quartile 3: 47.450 ~ < 51.350; Quartile 4: ≥ 51.350. iContinuous: as continuous variable; Low: < 3212.291; High: ≥ 3212.291; Quartile 1: < 1297.710; Quartile 2: 1297.710 ~ < 4134.754; Quartile 3: 4134.754 ~ < 7399.381; Quartile 4: ≥ 7399.381. jNormal: 0–1; Light: 2–4; Moderate: 5–8; Severe: 9–12.
Abbreviations: OS, overall survival; HR, hazard ratio; CI, confidence interval; Alb, serum albumin; Glb, serum globulin; CRP, C-reactive protein; Lym, lymphocyte; ALI, advanced lung cancer inflammation index; SII, systemic immune inflammation index; mGNRI, modified geriatric nutritional risk index; AGR, Alb-to-Glb ratio; PNI, prognostic nutritional index; LCR, Lym-to-CRP ratio; CONUT, controlling nutritional status score; mGPS, modified Glasgow prognostic score; LCS, Lym-to-CRP score.