1. Table of intervention variables.

Variable	TXA	Aprotinin	Epsilon‐aminocaproic acid	Desmopressin	Factor VIIa	Factor XIII	Fibrinogen	Fibrin sealants/glue	Non‐fibrin sealants
Timing
Pre‐hospital	✓	✓	✓	✓	X	X	X	✓	✓
Hospital	✓	✓	✓	✓	✓	✓	✓	✓	✓
Route
IV (injection, infusion)	✓	✓	✓	✓	✓	✓	✓	X	X
Topical	✓	X	X	X	X	X	X	✓	✓
Intranasal	X	X	X	✓	X	X	X	X	X
Subcutaneous injection	X	X	X	✓	X	X	X	X	X
IV + topical	✓	X	X	X	X	X	X	X	X
Oral	✓	X	✓	X	X	X	X	X	X
IV + oral	✓	X	X	X	X	X	X	X	X
Topical + oral	✓	X	X	X	X	X	X	X	X
Dose
Single	✓	X	✓	✓	✓	✓	✓	✓	✓
Multiple	✓	✓	X	✓	✓	✓	✓	X	X
Variable units/kg	✓	X	✓	X	✓	✓	✓	X	X
Variable trial‐set dose	✓	✓	X	✓	✓	✓	✓	✓	✓
The table is for illustrative purposes only and is based on the table from Gibbs 2019. Ticks indicate which intervention and timing/route/dose combinations are clinically possible; crosses indicate which intervention and timing/route/dose combinations are not clinically possible. IV: intravenous; TXA: tranexamic acid