Figure 10:
2D nanomaterials for drug delivery. (A) (Left) Schematic illustrations of Doxorubicin (DOX)182 and SN38156 loading onto PEGylated GO nanosheets (NGO-PEG). (Right, top) Relative cell viability as compared to untreated control of HCT-116 cells incubated with CPT-11, SN38, and NGO-PEG-SN38 at different concentrations. NGO-PEG-SN38 showed similar toxicity as SN38 in DMSO and much higher potency than CPT-11. (Right, bottom) Relative cell viability of HCT-116 cells after incubation with NGO-PEG with and without SN38. Plain NGO-PEG exhibited no obvious toxicity even at very high concentrations. Adapted with permission from ref.156 Copyright 2008 American Chemical Society. (B) 2D covalent organic nanosheet (CON) conjugated with folic acid (FA) molecules for targeted delivery of the anticancer drug, 5-fluorouracil (5-FU). Reproduced with permission from ref.164 Copyright 2017 American Chemical Society. (C) Photothermal drug delivery mechanism. Near infrared (NIR) light travels through biological tissues and heats a GO nanosheet, causing drug release. Reprinted from ref.,172 Copyright 2020, with permission from Elsevier. (D) 2D nanomaterial-mediated drug delivery in liposomes. GO nanosheets coat the liposomes and are irradiated with infrared light. The heated nanosheets cause drug release through heat-induced liposomal disruption.176