Table 2.
Time Varying Sample Characteristics
| Measurement Year Number of Patients Alive |
Baseline 1992–1993 n = 157 |
FU 1 1993 n = 151 |
FU 2 1994 n = 143 |
FU 3 1996 n = 136 |
FU 4 1997 n = 133 |
FU 5 1998 n = 131 |
FU 6 2001 n = 122 |
FU 7 2009 n = 96 |
|---|---|---|---|---|---|---|---|---|
| Number of patients that died in subsequent time interval (n) | 6 | 8 | 7 | 3 | 2 | 9 | 26 | 23 |
| Mean age (SD)a | 48.8 (15.6) | 53.0 (14.7) | 50.4 (13.9) | 53.8 (13.2) | 53.0 (12.7) | 54.5(12.7) | 55.5 (13.0) | 61.4 (10.7) |
| Medication | ||||||||
| Antipsychotics | ||||||||
| FGA only, n (%) | 146 (93.0) | 93 (84.5) | 104 (89.7) | 79 (86.8) | 74 (83.1) | 67 (79.8) | 72 (67.9) | 38 (48.1) |
| SGA only, n (%) | 0 | 8 (7.3) | 7 (6.0) | 9 (9.9) | 12 (13.5) | 10 (11.9) | 15(14.2) | 14 (17.7) |
| Combination FGA and SGA n (%) | 0 | 0 | 0 | 0 | 0 | 1 (1.2) | 13 (12.3) | 21 (26.6) |
| No antipsychotic, n (%) | 11 (7.0) | 9 (8.2) | 5 (4.3) | 3 (3.3) | 3 (3.4) | 6 (7.1) | 6 (5.7) | 6 (7.6) |
| DDD antipsychoticsb, mean (SD) | 1.8 (1.4) | 1.9 (1.5) | 2.0(1.3) | 2.0 (1.6) | 2.1 (1.5) | 2.4 (1.7) | 2.1 (1.6) | 2.4 (1.4) |
| Antidepressants, n (%)b | 9 (5.7) | 9 (8.1) | 9 (7.8) | 10 (11.0) | 7 (7.9) | 3 (3.6) | 10 (9.4) | 4 (5.0) |
| DDD antidepressantsb, mean (SD) | 0.9 (0.4) | 0.8 (0.4) | 0.9 (0.3) | 0.9 (0.4) | 0.8 (0.3) | 0.9 (0.3) | 1.1 (0.3) | 1.3 (0.5) |
| Benzodiazepines, n (%) | 29 (18.5) | 23 (20.1) | 34 (29.3) | 31 (34.0) | 31 (34.8) | 35 (41.7) | 52 (49.1) | 41 (51.3) |
| DDD benzodiazepinesb, mean (SD) | 1.4 (1.0) | 1.2 (0.9) | 1.0 (0.7) | 1.0 (0.8) | 1.2 (1.1) | 1.3 (1.2) | 1.2 (1.0) | 1.3 (1.0) |
| Movement disorders | ||||||||
| Tardive dyskinesia, cases (%) | 59 (37.6) | 59 (53.6) | 72 (61.5) | 56 (61.5) | 49 (53.3) | 43 (51.2) | 63 (59.4) | 41 (51.9) |
| Mean score cases AIMS (SD) | 7.5 (3.4) | 7.8 (2.7) | 9.6 (4.3) | 9.6 (4.0) | 9.3 (3.8) | 9.2 (3.8) | 9.9 (4.3) | 8.6 (3.2) |
| Parkinsonism, cases (%) | 56 (35.7) | 44 (40.0) | 37 (31.6) | 30 (33.0) | 26 (28.3) | 23 (27.4) | 37 (34.9) | 24 (30.4) |
| Mean score cases motor part UPDRS (SD) | 18.6 (10.1) | 18.5 (12.2) | 17.9 (11.2) | 22.4 (9.4) | 21.0 (10.2) | 22.7 (12.1) | 19.1 (12.3) | 15.5 (12.1) |
| Akathisia, cases (%) | 16(10.2) | 9 (8.2) | 15 (12.8) | 7 (7.7) | 2 (2.2) | 5 (6.0) | 5 (4.7) | 1 (1.3) |
| Mean score cases item 4 BARS | 2.6 (0.8) | 2.7 (0.7) | 2.8 (0.6) | 2.6 (0.8) | 2.5 (0.7) | 2.6 (0.5) | 2.8 (0.8) | 3.0 |
Note: FU: follow-up; FGA: first generations antipsychotic; SGA: second generation antipsychotic; DDD: Defined Daily Dose; AIMS: Abnormal Involuntary Movement Scale; UPDRS: Unified Parkinson Disease Rating Scale; BARS: Barnes Akathisia Rating Scale; AP: antipsychotics; AD: antidepressants; MD: movement disorders; TD: tardive dyskinesia.
aIn case of missing data about age and MD, no measurement had taken place at the respective FU.
Number of patients alive with missing data: FU1: all variables: n = 41; FU2: age and MD n = 26, medication: n = 27; FU3: all variables: n = 45; FU4: age and MD: n = 41, medication: n = 44; FU5: all variables: n = 47; FU6: all variables: n = 16; FU7: age: n = 18, AP: n = 18, AD: n = 17; benzodiazepines: n = 17; TD: n = 18, Parkinsonism: n = 18, akathisia: n = 19.
bMeans and SDs in DDD for the patients who used the respective medications are given.