Table 4.
Final Cox Proportional Hazards Model
| Variable | Hazard Ratio | 95% Confidence Interval | P Value |
|---|---|---|---|
| Female sex | 1.267 | 0.742–2.163 | .385 |
| Age | 0.995 | 0.937–1.056 | .863 |
| Age × time | 1.001 | 0.995–1.007 | .765 |
| Age linear-squared | 1.002 | 1.0004–1.0032 | .015* |
| Age linear-squared × time | 1.000 | 0.99975–1.0003 | .117 |
| Parkinsonism | 1.020 | 1.001–1.038 | .034* |
| DDD antipsychotics | 0.792 | 0.629–0.997 | .047* |
| DDD antipsychotics linear-squared | 1.154 | 0.993–1.340 | .061 |
| No antipsychotic** | 0.965 | 0.318–2.933 | .951 |
| FGA only** | 0.984 | 0.442–2.192 | .970 |
| Both FGA and SGA** | 1.021 | 0.254–4.104 | .976 |
Note: DDD: Defined Daily Dose; FGA: first generation antipsychotics; SGA: second generation antipsychotics.
*P < .05.
**Reference category: SGA only.