. 2022 May 12;48(4):814–825. doi: 10.1093/schbul/sbac027

Table 2.

Improvement of Different Outcome Parameters Over Time (After Intention-to-Treat Analysis)

Parameter	Time Points, Sphericity, Intragroup Comparisons	Group-1 (M-ECT) (n = 30)	Group-2 (Clozapine) (n = 30)	Between the Group Comparison (P value)^b
PANSS-P	Baseline	35.65 ± 0.89	35.78 ± 0.95	.925
	6 week	20.42 ± 0.74	29.93 ± 0.82	<.001
	12 week	15.62 ± 0.79	23.70 ± 1.07	<.001
	24 week	13.39 ± 0.70	19.89 ± 1.03	<.001
	Mauchly’s test of sphericity (P value)	<0.001	<0.001
	Greenhouse−Geisser (Ɛ)	0.515	0.613
	P value (with Greenhouse−Geisser correction)^a	<0.001	<0.001
	Baseline vs 6 weeks	<0.001	<0.001
	6 weeks vs 12 weeks	<0.001	<0.001
	12 weeks vs 24 weeks	<0.001	<0.001
PANSS-N	Baseline	36.96 ± 1.16	37.41 ± 1.21	.791
	6 week	26.23 ± 1.07	32.56 ± 1.23	<.001
	12 week	22.12 ± 1.03	28.04 ± 1.19	<.001
	24 week	19.96 ± 1.03	25.15 ± 1.39	<.001
	Mauchly’s test of sphericity (P value)	<0.001	<0.001
	Greenhouse−Geisser (Ɛ)	0.542	0.552
	P value (with Greenhouse−Geisser correction)^a	<0.001	<0.001
	Baseline vs 6 weeks	<0.001	<0.001
	6 weeks vs 12 weeks	<0.001	<0.001
	12 weeks vs 24 weeks	<0.001	<0.001
PANSS-G	Baseline	70.69 ± 1.77	70.85 ± 1.83	.950
	6 week	46.15 ± 1.86	60.00 ± 1.90	<.001
	12 week	38.27 ± 1.06	50.74 ± 1.92	<.001
	24 week	34.42 ± 1.23	43.44 ± 2.05	<.001
	Mauchly’s test of sphericity (P value)	<0.001	0.048
	Greenhouse−Geisser (Ɛ)	0.464	0.752
	P value (with Greenhouse−Geisser correction or Huynd−Feldt correction)^a	<0.001	<0.001
	Baseline vs 6 weeks	<0.001	<0.001
	6 weeks vs 12 weeks	<0.001	<0.001
	12 weeks vs 24 weeks	<0.001	<0.001
PANSS-T	Baseline	143.31 ± 2.58	144.04 ± 3.26	.862
	6 week	92.81 ± 2.11	122.48 ± 3.24	<.001
	12 week	76.00 ± 2.54	102.48 ± 3.63	<.001
	24 week	67.77 ± 2.67	88.48 ± 4.01	<.001
	Mauchly’s test of sphericity (P value)	<0.001	<0.001
	Greenhouse−Geisser (Ɛ)	0.515	0.609
	P value (with Greenhouse−Geisser correction)^a	<0.001	<0.001
	Baseline vs 6 weeks	<0.001	<0.001
	6 weeks vs 12 weeks	<0.001	<0.001
	12 weeks vs 24 weeks	<0.001	<0.001
GAF	Baseline	24.85 ± 1.09	22.11 ± 1.50	.149
	6 week	53.08 ± 1.76	30.59 ± 1.45	<.001
	12 week	63.39 ± 1.92	44.82 ± 2.38	<.001
	24 week	68.12 ± 2.06	51.33 ± 2.94	<.001
	Mauchly’s test of sphericity (P value)	0.001	<0.001
	Greenhouse−Geisser (Ɛ)	0.708	0.572
	P value (with Greenhouse−Geisser correction)^a	<0.001	<0.001
	Baseline vs 6 weeks	<0.001	<0.001
	6 weeks vs 12 weeks	<0.001	<0.001
	12 weeks vs 24 weeks	<0.001	<0.001
MOCA	Baseline	19.08 ± 0.43	19.22 ± 0.40	805
	6 week	20.27 ± 0.37	20.07 ± 0.39	722
	12 week	20.35 ± 0.35	20.74 ± 0.34	426
	24 week	20.46 ± 0.42	20.96 ± 0.32	.340
	Mauchly’s test of sphericity (P value)	<0.001	<0.001
	Greenhouse−Geisser (Ɛ)	0.662	0.596
	P value (with Greenhouse−Geisser correction)^a	<0.001	<0.001
	Baseline vs 6 weeks	<0.001	<0.001
	6 weeks vs 12 weeks	0.49	<0.001
	12 weeks vs 24 weeks	0.42	0.01
CGI-SCH-S	Baseline	6.192 ± 0.09	6.185 ± 0.11	.961
	6 week	3.69 ± 0.11	5.11 ± 0.13	<.001
	12 week	3.12 ± 0.12	4.15 ± 0.17	<.001
	24 week	3.00 ± 0.12	3.78 ± 0.19	<.001
	Mauchly’s test of sphericity (P value)	<0.001	0.012
	Greenhouse−Geisser (Ɛ)	0.656	0.732
	P value (with Greenhouse−Geisser correction)^a	<0.001	<0.001
	Baseline vs 6 weeks	<0.001	<0.001
	6 weeks vs 12 weeks	<0.001	<0.001
	12 weeks vs 24 weeks	0.083	0.022
CGI-SCH-I	6 week	2.27 ± 0.12	3.29 ± 0.10	<.001
	12 week	2.04 ± 0.14	2.67 ± 0.13	.002
	24 week	2.00 ± 0.14	2.56 ± 0.15	.007
	Mauchly’s test of sphericity (P value)	<0.001	<0.001
	Greenhouse−Geisser (Ɛ)	0.582	0.687
	P value (with Greenhouse−Geisser correction)^a	0.039	<0.001
	6 weeks vs 12 weeks	0.056	<0.001
	12 weeks vs 24 weeks	0.327	0.185

Data presented as mean ± SEM.

^aIntra-group (repeated measure ANOVA).

^bInter-group (repeated measure ANOVA).