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. 2022 Jan 29;48(4):795–803. doi: 10.1093/schbul/sbab153

Fig. 2.

Fig. 2.

MK-801-induced behavioral effects and their CB1/2r-mediated reversal by URB597. (A) In the OF, no group differences were observed in total distance travelled during 6 5 min bins (left), or in the time spent in the center during the first 5 min (right). (B) In the NOR test phase, no differences were observed in total exploration time (left), but a lower DI was observed in the MK+Veh group compared to Sal+Veh, and in the MK+URB+AM630 group compared to MK+URB (right). (C) In the SIT, MK+Veh rats demonstrated a lower sociability index (left), as well as increased non-social behavior (right) compared to Sal+Veh; the MK+URB+AM251 group had lower sociability index (left) and higher non-social behavior (right) compared to MK+URB. (D) In the Water T-maze, no group effects were found in the number of trials to criterion in the acq (left) or rev (right) phases. Bars represent group means and SEM. *CI P < .05, compared to the Sal+Veh or MK+URB groups, as described.