Table 2.
Incidence Rates (IR) of Psychotic Readmission During the Follow-up with Specific Antipsychotics
| Antipsychotics | No. of Events | Person-years (PY; %) | IR/10-PY (95% CI) |
|---|---|---|---|
| Total with use of antipsychotics | 143 191 | 277 849 (100.00) | 5.15 (5.13–5.18) |
| (1) Monopharmacy | 98 137 | 213 190 (76.73) | 4.60 (4.57–4.63) |
| First-generation oral antipsychotics | 19 941 | 45 082 (16.23) | 4.42 (4.36–4.48) |
| Chlorpromazine | 1225 | 2281 (0.82) | 5.37 (5.07–5.67) |
| Chlorprothixene | 72 | 130 (0.05) | 5.54 (4.26–6.82) |
| Flupentixol | 2439 | 4922 (1.77) | 4.95 (4.76–5.15) |
| Haloperidol | 5271 | 10 452 (3.76) | 5.04 (4.91–5.18) |
| Levomepromazine | 16 | 27 (0.01) | 5.87 (2.99–8.75) |
| Loxapine | 225 | 614 (0.22) | 3.66 (3.18–4.14) |
| Pimozide | 310 | 298 (0.11) | 10.40 (9.24–11.55) |
| Sulpiride | 8823 | 22 765 (8.19) | 3.88 (3.79–3.96) |
| Thioridazine | 309 | 735 (0.26) | 4.20 (3.73–4.67) |
| Trifluoperazine | 871 | 2 189 (0.79) | 3.97 (3.71–4.24) |
| Zuclopenthixol | 380 | 669 (0.24) | 5.68 (5.11–6.25) |
| First-generation LAIs | 2536 | 6571 (2.36) | 3.86 (3.71–4.01) |
| Flupentixol LAI | 1373 | 3103 (1.12) | 4.42 (4.19–4.66) |
| Fluphenazine LAI | 184 | 554 (0.20) | 3.32 (2.84–3.80) |
| Haloperidol LAI | 831 | 2483 (0.89) | 3.35 (3.12–3.57) |
| (Zu)clopenthixol LAI | 148 | 431 (0.16) | 3.43 (2.88–3.99) |
| Second-generation oral antipsychotics | 73 575 | 156 343 (56.27) | 4.71 (4.67–4.74) |
| Amisulpride | 5306 | 14 077 (5.07) | 3.77 (3.67–3.87) |
| Aripiprazole | 4370 | 12 129 (4.37) | 3.60 (3.50–3.71) |
| Clotiapine | 1216 | 1981 (0.71) | 6.14 (5.79–6.48) |
| Clozapine | 10 747 | 19 965 (7.19) | 5.38 (5.28–5.48) |
| Lurasidone | 18 | 14 (0.01) | 12.80 (6.89–18.72) |
| Olanzapine | 9552 | 22 248 (8.01) | 4.29 (4.21–4.38) |
| Paliperidone | 3281 | 6553 (2.36) | 5.01 (4.84–5.18) |
| Quetiapine | 11 825 | 17 529 (6.31) | 6.75 (6.62–6.87) |
| Risperidone | 21 622 | 51 499 (18.53) | 4.20 (4.14–4.25) |
| Ziprasidone | 1173 | 2384 (0.86) | 4.92 (4.64–5.20) |
| Zotepine | 4465 | 7964 (2.87) | 5.61 (5.44–5.77) |
| Second-generation LAIs | 2078 | 5161 (1.86) | 4.03 (3.85–4.20) |
| Paliperidone LAI 28 | 483 | 823 (0.30) | 5.87 (5.34–6.39) |
| Risperidone LAI | 1595 | 4338 (1.56) | 3.68 (3.50–3.86) |
| Other | 7 | 33 (0.01) | 2.12 (0.55–3.69) |
| (2) Polypharmacy | 45 054 | 64 659 (23.27) | 6.97 (6.90–7.03) |