Fig 6. Weighted cumulative incidence plots of the primary and secondary end points.

The primary endpoint of the study was estimated glomerular filtration rate (estimated by the CKD EPI formula) of more than 30% from the baseline (Panels a, b, c). The secondary endpoint of the study was the first observation of the albumiunria (defined by the urine albumin creatinine ratio greater or equal to 30mg/mmol) (Panels d, e, f). The study cohorts are SAVOR (Panels a, d), CPRD-DM2 (Panels b, e), CPRD- (Panels c, f). High bilirubin plotted in red are the patient subpopulation that has above or equal cohort median of the baseline serum bilirubin concentration (9μmol/L for SAVOR, 10μnil/L for CPRD-DM2 and HT), Low bilirubin plotted in blue are the patient subpopulation that has below cohort median of the baseline serum bilirubin concentration, The cumulative incidences were estimated with the use of the Kaplan–Meier method where the events are weighted by the inverse probability weighting scheme with the propensity score calculated based on the confounding covariates (age, sex, race if available, baseline body mass index, baseline hemoglobin, baseline alanine transaminase, baseline aspartate transaminase, smoking).