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. Author manuscript; available in PMC: 2022 Sep 8.
Published in final edited form as: Hypertension. 2021 Sep 8;78(4):1027–1038. doi: 10.1161/HYPERTENSIONAHA.121.16981

Figure 2.

Figure 2.

BP analysis of DCT PRR KO mice during high Na+ (HS, 4% NaCl) diet treatment. (A-F) BP was monitored daily by radiotelemetry following a HS diet. At day24, both floxed and DCT PRR KO mice were all subjected to hydrochlorothiazide (HCTZ) (100 mg/L added to drinking water) treatment for 6 days. (A) MAP, (B) SBP, (C) DBP, (D) HR. Data are means ± SEM; n = 4 per group. &p<0.001 (C), &p=0.01 (D), &p=0.001 (E), and &p=0.214 (F) (analysis of the interaction [time × strain] by repeated-measures ANOVA). *p<0.05, **p<0.01, ***p<0.001 vs. Floxed at the corresponding time period (unpaired Student’s t test); #p<0.05 vs. Day 24 (unpaired Student’s t test). (E, F) Change in ΔMAP, ΔSBP, ΔDBP (E), and heart rate (ΔHR) (F) after HCTZ treatment for 6 days, determined by the delta value of BP or HR at Day24 and Day30. Data are means ± SEM; n = 4 per group. *p<0.05, **p<0.01 vs. Floxed + HS (unpaired Student’s t test).