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. Author manuscript; available in PMC: 2022 Jun 21.
Published in final edited form as: Head Neck. 2013 Nov 29;36(8):1207–1215. doi: 10.1002/hed.23439

FIGURE 6.

FIGURE 6.

Effect of incisional biopsy on circulating tumor cell (CTC) counts (B16F10-green fluorescent protein [GFP]). (A) Dynamic of average CTC counts per 10-minute window for 70 minutes before, 15 minutes during (yellow region), and 260 minutes after incisional biopsy. Values and error bars represent the averages and SDs of CTC counts from 5 mice during each 10-minute bin. (B) Tumor after incisional biopsy. (C) CTC detection rates in counts per 10 minutes before versus during biopsy, and before versus after biopsy. Values (error bars) represent the estimates (90% confidence intervals) determined from mixed-models Poisson-regression analysis. (D) Example of CTCs release before and after 2 different incisional biopsies in the same mouse (B16F10-GFP) (duration of each incisional biopsy: approximately 1 minute).