FIGURE 9.

Melanoma circulating tumor cell (CTC) rate in ear blood vessel at different stages of tumor development for 18 mice with skin and ear melanoma. (A) CTC dynamic versus tumor volume of the subcutaneous melanoma tumor model measured by in vivo photoacoustic and fluorescence flow cytometry during 3 weeks after tumor implantation (Spearman correlation = 0.456; p = .057). (B) CTC dynamic and tumor size versus tumor growth in the subcutaneous melanoma model. Tumor size versus tumor growth: spearman correlation 0.705; p = .0007 and CTC dynamic versus tumor growth: spearman correlation 0.211; p = .37. The volume (size) was calculated using standard clinical method.